63843-49-2Relevant academic research and scientific papers
N- versus O-arylation of aminoalcohols: Orthogonal selectivity in copper-based catalysts
Shafir, Alexandr,Lichtor, Phillip A.,Buchwald, Stephen L.
, p. 3490 - 3491 (2008/01/01)
Two complementary protocols for copper-catalyzed arylation of aminoalcohols were developed. Selective N-arylation was accomplished at room temperature using 2-isobutyrylcyclohexanone (a β-diketone) as supporting ligand, while selective O-arylation require
Oxamides as novel NR2B selective NMDA receptor antagonists
Barta-Szalai, Gizella,Borza, Istvan,Bozo, Eva,Kiss, Csilla,Agai, Bela,Proszenyak, Agnes,Keseru, Gyoergy M.,Gere, Aniko,Kolok, Sandor,Galgoczy, Kornel,Horvath, Csilla,Farkas, Sandor,Domany, Gyoergy
, p. 3953 - 3956 (2007/10/03)
A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.
Piperidylalkylindoles. 1. Hypotensive activity of 3-[2-(phenoxypiperidyl)ethyl]indoles
Helsley,Strupczewski,Woodward
, p. 309 - 312 (2007/10/05)
A series of 3-[2-(phenoxypiperidyl)ethyl]indoles was synthesized and evaluated for hypotensive activity in the spontaneous hypertensive rat. Maximum hypotensive activity appeared when the phenoxy substituent was para substituted and occupied the 4 position of the piperidine ring.
Method of treating pain and hypertension
-
, (2008/06/13)
3-[2-(Phenyloxycycloazalkyl)ethyl]indoles possessing antihypertensive, analgesic, and tranquilizing properties and process for their preparation are described.
