63857-19-2

Basic information

• Product Name: Benzenepropanoic acid, a-formyl-, methyl ester
• CAS NO: 63857-19-2
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Mol File: 63857-19-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-formyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-formyl-, methyl ester(63857-19-2)
• EPA Substance Registry System: Benzenepropanoic acid, a-formyl-, methyl ester(63857-19-2)

Safety Data

• Hazardous Substances Data: 63857-19-2(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 103-26-4 Methyl cinnamate 
• 591-50-4 iodobenzene 
• 15484-46-5 methyl 2-hydroxymethylacrylate 
• 107-31-3 Methyl formate 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 109-94-4 formic acid ethyl ester 
• 103-26-4 methyl cinnamate 

Downstream Products

• 1233560-08-1 6-(4-benzyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)-N-ethyl-N-phenylpyridine-3-sulfonamide 
• 709673-94-9 (R)-2-benzyl-3-hydroxypropanoic acid methyl ester 
• 63857-13-6 2-(Diisopropyl-hydrazonomethyl)-3-phenyl-propionic acid methyl ester 
• 63857-12-5 2-(Diethyl-hydrazonomethyl)-3-phenyl-propionic acid methyl ester 

Relevant articles and documents

Insertion of Alkylidene Carbenes into B-H Bonds

We have developed a protocol for insertion of alkylidene carbenes into the B-H bonds of amine-borane adducts, enabling, for the first time, the construction of C(sp2)-B bonds by means of carbene-insertion reactions. Various acyclic and cyclic alkenyl borane-amine adducts were prepared from readily accessible starting materials in good to high yields and were subsequently subjected to a diverse array of functional group transformations. The unprecedented spiro B-N heterocycles prepared in this study have potential utility as building blocks for the synthesis of pharmaceuticals. Preliminary mechanistic studies suggest that insertion of the alkylidene carbenes into the B-H bonds of the amine-borane adducts proceeds via a concerted process involving a three-membered-ring transition state.

Highly regioselective rhodium-catalysed hydroformylation of unsaturated Esters: The first practical method for quaternary selective carbonylation

Highly regioselective hydroformylation of unsaturated esters can be achieved when a highly reactive, ligand-modified, rhodium catalyst is employed near ambient temperatures (15-50°C) and pressures over 30 bar. The use of 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phosphaadamantane shows distinct advantages over other commonly applied phosphanes in terms of reaction rate, and regio- and chemoselectivity. Hydroformylation of a range 1,1-di- and 1,1,2-trisubstituted unsaturated esters yields quaternary aldehydes that are forbidden products according to Keulemans Rule. The aldehydes can be reductively aminated with molecular hydrogen to give β-amino acid esters in high yield. The overall green chemical process involves converting terminal alkynes into unusual β-amino acid esters with only water generated as an essential byproduct. This catalytic system has also been applied to the hydroformylation of simple 1,2-disubstitued unsaturated esters, which have been hydroformylated with excellent α-selectivity and good chemo-selectivity for the first time.

Catalytic TMSCl promoted powerful aldol addition and Claisen condensation mediated by TiCl4/Bu3N agent: Comparison and evaluation with the Mukaiyama aldol addition

TMSCl catalyst (0.05 equiv) significantly promoted the TiCl4/Bu3N-mediated direct cross aldol additions of sterically crowded ketones and α-hetero substituted ketones, and also the direct Claisen condensation between methyl esters.