63870-44-0

Upstream product

• 51694-22-5 ortho-nitrophenyl selenocyanate 
• 35350-43-7 bis(o-nitrophenyl) diselenide 
• 7722-84-1 dihydrogen peroxide 
• 78163-72-1 o-aminoselenophenol 
• 615-43-0 2-iodophenylamine 
• 609-73-4 o-nitroiodobenzene 
• 615-36-1 2-bromoaniline 
• 56790-58-0 2-nitro-benzeneselenenyl bromide 
• 88-73-3 2-Chloronitrobenzene 

Downstream Products

• 70086-67-8 2-(methylselanyl)aniline 
• 873412-54-5 2-ethylselanyl-aniline 
• 78163-72-1 o-aminoselenophenol 
• 524951-85-7 N,N'-(2,2'-diselanediyl-diphenyl)-bis-carbamic acid diethyl ester 
• 465532-54-1 C₂₆H₃₄N₄O₂Se₂ 
• 465532-53-0 C₂₂H₃₀N₄O₂Se₂ 
• 465532-55-2 bis[[2-(N-phenylthiocarbamoyl)amino]phenyl]diselenide 
• 352531-75-0 (C₆H₅)3PNP(C₆H₅)3⁽¹⁺⁾*Mn(CO)3SeC₆H₄NH^(1-)=(C₆H₅)3PNP(C₆H₅)3Mn(CO)3SeC₆H₄NH 
• 1236253-06-7 1,2-bis(2-azidophenyl)diselenide 
• 1420841-18-4 2-(4-bromophenyl)benzo[d][1,3]selenazole 
• 32586-68-8 2-phenylbenzo[d][1,3]selenazole 
• 1420841-22-0 2-(4-methoxyphenyl)benzo[d][1,3]selenazole 
• 1420841-23-1 2-(p-tolyl)benzo[d][1,3]selenazole 
• 1420841-25-3 2-(3,4-difluorophenyl)benzo[d][1,3]selenazole 

Relevant academic research and scientific papers

New 3,1,2,4-benzothiaselenadiazines, related π-heterocycles including Herz cations, radicals and molecular complexes, and Bunte salts

New chalcogen-nitrogen π-heterocycles covering 3,1,2,4-benzothiaselenadiazines, 1,3,2,4-benzodithiadiazines and 1,2,4,3,5-benzotrithiadiazepines were synthesized via the electrophilic cyclization of compounds Ar-NSN-SiMe3 under the action of SeCl2, SeCl4/FeCp2, SCl2 and S2Cl2. Heterocycles obtained were thermolyzed into persistent 2,1,3-benzothiaselenazolyls and 1,2,3-benzodithiazolyls (Herz radicals), which were characterized using EPR spectroscopy and DFT calculations. Reaction of the archetypal 3,1,2,4-benzothiaselenadiazine with SCl2 afforded 2,1,3-benzothiaselenazolium chloride (Herz salt), whereas that of sterically hindered 1,3,2,4-benzodithiadiazine resulted in a complex of the corresponding Herz salt with unexpected carbocycle-chlorinated and non-chlorinated 3,3-dioxides of the starting material, which is a rare example of a molecular complex involving a Herz cation. Formation of the dioxides can be explained through intermediate participation of the benzodithiadiazine radical cation. Hydrolysis of 3,1,2,4-benzothiaselenadiazine or 1,3,2,4-benzodithiadiazine led to Se-(2-aminophenyl)selenosulfate (Se-Bunte salt) or S-(2-aminophenyl)thiosulfate (Bunte salt), respectively. This journal is

Catalytic antioxidant activity of bis-aniline-derived diselenides as GPx mimics

Herein, we describe a simple and efficient route to access aniline-derived diselenides and evaluate their antioxidant/GPx-mimetic properties. The diselenides were obtained in good yields via ipso-substitution/reduction from the readily available 2-nitroaromatic halides (Cl, Br, I). These diselenides present GPx-mimetic properties, showing better antioxidant activity than the standard GPx-mimetic compounds, ebselen and diphenyl diselenide. DFT analysis demonstrated that the electronic properties of the substituents determine the charge delocalization and the partial charge on selenium, which correlate with the catalytic performances. The amino group concurs in the stabilization of the selenolate intermediate through a hydrogen bond with the selenium.

Green preparation method of aryl diselenium ether type organic selenium compound

The invention discloses an aryl diselenium ether compound synthesis method. The synthesis method comprises the following steps: taking the compound represented by the formula (I) as a reaction raw material, CuBr as a catalyst, KOH in the condition Se, a reducing agent, a disproportionation reaction, water or ethanol as a solvent, and 60 °C. After completion of the reaction, the obtained reaction solution is subjected to post-treatment (if ethanol is recovered as solvent) to obtain the aryl diselenoether compound represented by the formula (II), the yield is close 100%, the subsequent treatment is simple, and a complex separation and purification method is not needed to obtain a pure product. The solvent is recovered as a solvent such as ethanol. , It is preferable. The method is more green. Economy, high efficiency, environmental protection.

Janus -faced oxidant and antioxidant profiles of organo diselenides

To date, organoseleniums are pre-eminent for peroxide decomposition and radical quenching antioxidant activities. On the contrary, here, a series of Janus-faced aminophenolic diselenides have been prepared from substituted 2-iodoaniline and selenium powder using copper-catalyzed methodology. Subsequently, condensation with substituted salicylaldehyde afforded the Schiff base, which on reduction, yielded the desired substituted aminophenolic diselenides in 72%-88% yields. The generation of reactive oxygen species (ROS) from oxygen gas by the synthesized aminophenolic diselenides was studied by analyzing the oxidation of dichlorofluorescein diacetate (DCFDA) dye and para-nitro-thiophenol by fluorescence and UV-Visible spectroscopic methods. Furthermore, density functional theory calculations and crystal structure analysis revealed the role of functional amine and hydroxyl sites present in the Janus-faced organoselenium catalyst for the activation of molecular oxygen, where NH and phenolic groups bring the oxygen molecule close to the catalyst by N-H?O and O-H?O intermolecular interactions. Additionally, these functionalities stabilize the selenium-centered radical in the formed transition states. Antioxidant activities of the synthesized diselenides have been explored as the catalyst for the decomposition of hydrogen peroxide using benzenethiol sacrificial co-reductant by a well-established thiol assay. Radical quenching antioxidant activity was studied by the quenching of DPPH radicals at 516 nm by UV-Visible spectroscopy. The structure activity correlation suggests that the electron-rich phenol and electron-rich and sterically hindered selenium center enhance the oxidizing property of the aminophenolic diselenides. Janus-faced diselenides were also evaluated for their cytotoxic effect on HeLa cancer cells via MTT assay, which suggests that the compounds are effective at 15-18 μM concentration against cancer cells. Moreover, the combination with therapeutic anticancer drugs Erlotinib and Doxorubicin showed promising cytotoxicity at the nanomolar concentration (8-28 nM), which is sufficient to suppress the growth of the cancer cells. This journal is

Benzo five-membered ring aza derivative containing benzophenone group as well as preparation method and application of benzo five-membered ring aza derivative

The invention discloses a benzo five-membered ring aza derivative containing a benzophenone group as well as a preparation method and application of the benzo five-membered ring aza derivative. The benzo five-membered ring aza derivative containing the benzophenone group has a unique benzophenone group and benzo five-membered ring aza structure, has unique intramolecular twisted charge transfer (TICT) and aggregation-induced emission (AIE) effects, has high luminous intensity, red light emission and delayed fluorescence, and can be well used as a luminous layer in a red light OLED. Controllable preparation of the benzo five-membered ring aza derivative containing the benzophenone group is achieved, the preparation cost is low, the raw material source is wide, and large-scale production can be achieved. The benzo five-membered ring aza derivative containing the benzophenone group can be widely applied to the fields of color display and solid-state illumination, is used for preparing luminous materials, luminous devices or intelligent materials, and is particularly used for preparing OLED devices.

Non-covalent bridging of bithiophenes through chalcogen bonding grips

In this work, chalcogen functionalized dithiophenes, equipped on both extremities with chalcogen-bonding recognition heterocycles, have been prepared following two synthetic pathways. The insertion of the chalcogenazolo[5,4-β]pyridine allows the control of the organization at the solid state. X-Ray diffraction analysis of the single crystals, showed that the Te-doped derivatives give the most persistant assemblies, with the molecules arranging at solid-state in wire-like polymeric structures through Te?N interactions. As expected, the introduction of the Se and Te atoms, dramatically decreases the emission properties, with the Te-bearing congeners being virtually non emissive.

Emission color-tunable oxazol(in)yl-substituted excited-state intramolecular proton transfer (ESIPT)-based luminophores

Oxazolinyl- and arylchalcogenazolyl-substituted hydroxyfluorenes exhibiting excited-state intramolecular proton transfer (ESIPT) are described as potent and highly modular luminophores. Emission color tuning was achieved by varying the π-expansion and the

Isolation and structure of an 18-membered macrocycle containing two diselenide linkages and its precursor

The structures of the 18-membered diselenide-linked macrocycle 10,27-di-tert-butyl 11,28-dioxo-2,3,19,20-tetraselena-10,12,27,29-tetraazapentacyclo-[28.4.0.04,9.013,18.021,26]tetratriaconta-1(30),4(9),5,7,13,15,17,21,23,25

Se-mediated one-pot synthesis of 2-substituted benzoselenazole derivatives from 2 to iodoanilines and arylacetic acids/arylmethyl chlorides

A general approach to the formation of 2-substituted benzoselenazoles from the three-component reactions of 2-iodoanilines, selenium powder, arylacetic acids or benzyl chlorides is described. The use of copper salt as catalyst and dimethyl sulfoxide (DMSO) as solvent are crucial to afford the title compounds in moderate to good yields (45–88%) with good functional group tolerance on the aromatic and heteroaromatic substrates.

An Organodiselenide with Dual Mimic Function of Sulfhydryl Oxidases and Glutathione Peroxidases: Aerial Oxidation of Organothiols to Organodisulfides

A novel organodiselenide, which mimics sulfhydryl oxidases and glutathione peroxidase (GPx) enzymes for oxidation of thiols by oxygen and hydrogen peroxide, respectively, into disulfides has been presented. The developed catalyst oxidizes an array of organothiols into respective disulfides in practical yields by using aerial O2 to avoid any reagents/additives, base, and light source. The synthesized diselenide also catalyzes the reduction of hydrogen peroxide into water by following the GPx enzymatic catalytic cycle with a reduction rate of 49.65 ± 3.7 μM·min-1.