63873-61-0

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLOROTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique molecular structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 4-CHLOROTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE serves as an essential intermediate for the synthesis of pesticides. Its properties allow for the creation of effective pest control agents, enhancing crop protection and yield.
Used in Organic Synthesis:
4-CHLOROTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE is utilized as a building block in organic synthesis for the production of a wide range of chemical compounds. Its versatility and reactivity make it a valuable component in the synthesis of various organic molecules for different applications.
It is crucial to handle 4-CHLOROTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE with care and follow safety guidelines to minimize potential hazards associated with its use.

Upstream product

• 63873-60-9 4-hydroxythieno[2,3-b]pyridine-5-carbonitrile 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 700844-20-8 4-chlorothieno[3,2-b]pyridine-5-carboxamide 
• 65075-97-0 ethyl α-cyano-β-(N-2-thienylammonium)acrylate 
• 700844-19-5 4-chlorothieno[3,2-b]pyridine-5-carboxylic acid 
• 59713-58-5 ethyl 4-chlorothieno<2,3-b>pyridine-5-carboxylate 

Downstream Products

• 700844-18-4 4-chloro-2-iodothieno[3,2-b]pyridine-5-carbonitrile 
• 908274-68-0 4-(3-fluoro-phenylamino)-thieno[2,3-b]pyridine-5-carbonitrile 
• 908274-66-8 4-(3-methoxy-phenylamino)-thieno[2,3-b]pyridine-5-carbonitrile 
• 908274-71-5 4-p-tolylamino-thieno[2,3-b]pyridine-5-carbonitrile 
• 908274-72-6 4-(4-methoxy-phenylamino)-thieno[2,3-b]pyridine-5-carbonitrile 
• 908274-69-1 4-(3-chloro-phenylamino)-thieno[2,3-b]pyridine-5-carbonitrile 
• 700844-39-9 4-[(2,4-dichloro-5-methoxyphenyl)amino]-2-iodothieno[3,2-b]pyridine-5-carbonitrile 
• 700844-59-3 4-[(2,4-dichloro-5-methoxyphenyl)amino]-2-(4-formylphenyl)thieno[3,2-b]pyridine-5-carbonitrile 
• 700844-38-8 4-[ (3-Chloro-4-[ (1-methyl-1 H-imidazol-2-yl) thio] phenyl) amino] thieno [2,3-b] pyridine-5-carbonitrile 
• 908274-74-8 4-(4-fluoro-phenylamino)-thieno[2,3-b]pyridine-5-carbonitrile 
• 908274-70-4 4-(3-bromo-phenylamino)-thieno[2,3-b]pyridine-5-carbonitrile 
• 908274-67-9 4-(3-nitro-phenylamino)-thieno[2,3-b]pyridine-5-carbonitrile 
• 908274-64-6 4-phenylamino-thieno[2,3-b]pyridine-5-carbonitrile 
• 908274-73-7 4-(4-nitro-phenylamino)-thieno[2,3-b]pyridine-5-carbonitrile 

Relevant academic research and scientific papers

Synthesis, crystal structures, and in silico toxicity prediction of thienopyridine phosphoramidates

New thieno[2,3-b]pyridine phosphoramidates compounds were synthesized and characterized by infrared; 1H, 13C, and 31P NMR spectroscopy; and high-resolution mass spectrometry. The products were obtained in good yields (64-82%) under mild conditions by nucleophilic aromatic substitution reaction of aminoalkylphosphoramidates over 4-chlorothieno[2,3-b] pyridine-5-carbonitrile. The crystal structures of two compounds were solved by X-ray diffraction and showed a network of intermolecular interactions involving phosphoramidate groups. Druglike properties and toxicity of the new compounds were studied with the help of the software Molinspiration, Osiris, and Toxtree, and were compared with the standard drugs amphotericin B, miltefosine, benznidazole, and nifurtimox. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives

Antibacterial resistance is a complex problem that contributes to health and economic losses worldwide. The Staphylococcus epidermidis is an important nosocomial pathogen that affects immunocompromised patients or those with indwelling devices. Currently,

Identification of 7-phenylaminothieno-[3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors

We disclose here a new class of kinase inhibitors, obtained by replacing the phenyl ring of a 3-quinolinecarbonitrile system with a thiophene ring. When suitably substituted, the resultant 7-phenylaminothieno[3,2-b]pyridine-6- carbonitrile analogues show

THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS

This invention provides compounds of Formula (1 a) - (1f) wherein:X, R1, and R2 are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.

Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors

This invention provides compounds of Formula (1a)-(1f), II wherein: X, m, n, q, R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Q, Z, Z′, Z′″, Z″ and J are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.