63874-26-0

Upstream product

• 59643-84-4 2-n-propoxybenzamide 
• 65-45-2 salicylamide 

Downstream Products

• 127488-11-3 3-methylthio-8-oxo-6-(2-propoxyphenyl)-7,8-dihydropyrimido[4,5-e][1,2,4]triazine 
• 127957-37-3 7-methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine 
• 1229018-87-4 N-(3-(5,6-diethyl-4(3H)-pyrimidone-2-yl)-4-n-propoxyphenyl)-2-(4-methylpiperazin-1-yl)acetamide 
• 1229017-38-2 2-(5-nitro-2-n-propoxyphenyl)-5,6-diethyl-4(3H)-pyrimidone 
• 1229017-39-3 2-(5-amino-2-n-propoxyphenyl)-5,6-diethyl-4(3H)-pyrimidone 
• 1229018-85-2 2-chloro-N-(3-(4,5-diethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl) acetamide 
• 1229020-08-9 C₁₆H₁₈BrClN₂O₄S 
• 1229017-34-8 N-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-N',N',N''-triethylguanidine 
• 1229017-74-6 5-bromo-6-isopropyl-2-(2-propoxy-5-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)amino)phenyl)pyrimidin-4(3H)-one 
• 1229017-47-3 N-(3-(5-bromo-4-isopropyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl)methanesulfonamide 
• 1229017-32-6 1-(3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl)-3-ethylthiourea 
• 1229017-33-7 1-[3-(4-isopropyl-5-bromo-1,6-dihydro-6-oxopyrimidin-2-yl)-4-n-propoxyphenyl]-3-ethyl-2-methylisothiourea 
• 1229017-30-4 5-bromo-6-isopropyl-2-(5-nitro-2-propoxyphenyl)pyrimidin-4(3H)-one 
• 1229019-43-5 2-(2-n-propoxyphenyl)-6-isopropylpyrimid-4(3H)-one 

Relevant academic research and scientific papers

Facile and Cost-Effective Route for the Synthesis of Simmerafil

An improved synthesis of simmerafil, a potent PDE5 inhibitor as a clinical candidate, is described with a 38.1% overall yield and 99.7% purity. Starting from the safe and inexpensive salicylamide (15), the key intermediate 2-propoxybenzimidamide (21), which is also a potential precursor for the preparation of pyrimidinone derivatives, was effectively and conveniently obtained. The subsequent process from21to simmerafil was optimized, which makes it more amenable to scale-up.

PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF

The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates to a type of phenylpyrimidone compounds of the following f

1,6-Dihydro-6-oxo-2-(ortho-substituted phenyl)pyrimidine-5-carboxylic acid derivatives

A series of 1,6-dihydro-6-oxo-2-(ortho-substituted phenyl)pyrimidine-5-carboxylic acid derivatives is provided for use as inhibitors of allergic reactions. The compounds show antiallergy activity by both oral and parenteral routes of administration.