63881-16-3

Usage

Uses

Used in Pharmaceutical Research:
[2-(2-METHOXY-ETHOXY)-ETHOXY]-ACETYL CHLORIDE is used as an intermediate for the synthesis of various organic compounds in pharmaceutical research. Its high reactivity and ability to acetylate a wide range of functional groups make it a valuable tool in the development of new pharmaceuticals.
Used in Agrochemical Production:
In the agrochemical industry, [2-(2-METHOXY-ETHOXY)-ETHOXY]-ACETYL CHLORIDE is used as a building block in the synthesis of various agrochemicals. Its versatility in acetylating different functional groups contributes to the development of effective agrochemical products.
Used in Fine Chemicals Synthesis:
[2-(2-METHOXY-ETHOXY)-ETHOXY]-ACETYL CHLORIDE is used as a key intermediate in the production of fine chemicals. Its reactivity and functional group acetylating capabilities are essential in creating a diverse range of specialty chemicals.
Used in Polymer Production:
[2-(2-METHOXY-ETHOXY)-ETHOXY]-ACETYL CHLORIDE is used as a reagent in the production of polymers. Its role in this application is crucial for the development of polymers with specific properties tailored to various industrial needs.
Used in Industrial Processes as a Solvent:
[2-(2-METHOXY-ETHOXY)-ETHOXY]-ACETYL CHLORIDE is also utilized as a solvent in various industrial processes. Its unique properties make it suitable for use in a range of applications, contributing to the efficiency and effectiveness of these processes.

Upstream product

• 16024-58-1 2-[2-(2-methoxyethoxy)etoxy]acetic acid 
• 112-35-6 triethylene glucol monomethyl ether 

Downstream Products

• 75427-80-4 3-Benzyloxypropylenbis(3,6,9-trioxadecanoat) 
• 75427-85-9 2-Benzyloxy-3-(3,6,9-trioxadecanoyloxy)propyl-3,6,9,12-tetraoxatetradecanoat 
• 135658-21-8 11,22,33-tris(benzyloxy)-12,15,23,26,34-pentaoxo-11,16,22,27,33-pentaaza-2,5,8,36,39,42-hexaoxatritetracontane 
• 250651-14-0 3-{N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]amino}-2,4,6-trimethylphenyl 2-[2-(2-methoxyethoxy)ethoxy]acetate 
• 1234619-60-3 N-{(7R)-6-Cyano-7-(4-cyanophenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}-2-[2-(2-methoxyethoxy)ethoxy]acetamide 
• 1220112-70-8 N,N-dimethyl-3-(2-(N-methyl-3-(2-(N-methyl-3-(2-(2-(2-methoxyethoxy)ethoxy)acetamido)benzamido)acetamido)benzamido)acetamido)benzamide 
• 1220112-69-5 C₂₆H₃₄N₄O₇ 
• 63881-19-6 3-Amino-2,4,6-triiodo-5-({2-[2-(2-methoxy-ethoxy)-ethoxy]-acetyl}-methyl-amino)-benzoic acid 
• 63881-18-5 3-Amino-2,4,6-triiodo-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-benzoic acid 
• 63881-17-4 3-Amino-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-benzoic acid 
• 63881-15-2 3-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-acetylamino}-5-nitro-benzoic acid 

Relevant academic research and scientific papers

Nanofiltration membranes with modified active layer using aromatic polyamide dendrimers

The modification of a commercial nanofiltration (NF) membrane (TFC-S) with shape-persistent dendritic molecules is reported. Amphiphilic aromatic polyamide dendrimers (G1-G3) are synthesized via a divergent approach and used for membrane active layer modi

Self-diffusion of hydrophilic poly(propyleneimine) dendrimers in poly(vinyl alcohol) solutions and gels by pulsed field gradient NMR spectroscopy

Pulsed-field gradient NMR spectroscopy was used to study the diffusion of three different poly(propyleneimine) dendrimers with hydrophilic triethylenoxy methyl ether terminal groups (generations 2, 4, and 5) in poly(vinyl alcohol) aqueous solutions and gels. The effects of the diffusant size, polymer concentration (from 0 to 0.26 g/mL), and temperature on the self-diffusion coefficients have been studied, and the model of Petit et al. [Macromolecules 1996, 29, 6031] was used to fit the experimental data. The Stokes-Einstein hard-sphere radii were also calculated in the zero concentration limit and were compared with those of the linear poly(ethylene glycol)s under the same conditions. The proton NMR relaxation times (T1 and T2) were measured to study the mobility of the dendrimer core part and terminal group as a function of the dendrimer size.

Synthesis of Vitamin-B12 Derivatives with Peripheral Tris(oxyethylene) Chains

The new derivatives 7a-c, of vitamin B12, with a peripheral tris(oxyethylene) chain linked to the corrin ring by an amide or ester group, are prepared, and their ligand-exchange reactions are investigated. Upon reduction of the aqua-cyano complexes 8a-c with NaBH4, cleavage of the 'outer' ester and amide group is observed.

Water-soluble aminocurdlan derivatives by chemoselective azide reduction using NaBH4

Water-solubility can often enhance the utility of polysaccharide derivatives, for example in pharmaceutical and biomedical applications. Synthesis of water-soluble aminopolysaccharides, particularly those bearing other sensitive functional groups, can be a challenging endeavor. Curdlan is a bioactive β-1,3-glucan with considerable promise for biomedical applications. Aminocurdlans are intriguing target molecules for study of, for example, their interactions with the proteins that form tight junctions between enterocytes. Herein we report the preparation of two water-soluble 6-aminocurdlans starting from 6-bromo-6-deoxycurdlan. The 6-bromide was first displaced by nucleophilic substitution with sodium azide in dimethyl sulfoxide. The O-2 groups were acylated with hydrophilic oligo (ethylene oxide) esters, so as to enhance aqueous solubility. The resultant 6-azido-6-deoxy-2,4-di-O-trioxadecanoylcurdlan was then treated with excess sodium borohydride to reduce the azide; unexpectedly, the water-soluble product proved to be the amide, 6-trioxadecanamido-6-deoxycurdlan. Regioselectivity and degree of substitution (DS) of those derivatives were characterized by means of 1H NMR, 13C NMR and FTIR-spectroscopy, elemental analysis, and titration. Alternatively, direct borohydride reduction of the parent 6-azido-6-deoxycurdlan afforded 6-amino-6-deoxycurdlan that was also water-soluble.

NOVEL OPIOID COMPOUNDS AND USES THEREOF

This invention relates to novel opioid derivatives of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R3, R4 and Z are as defined herein in the disclosure. The invention also relates to the use of such compounds for the treatment or prevention of, for example, pain.

Optically-Detectable Enzyme Substrates and Their Method of Use

The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactmase or instructions for using the components in an assay.

A hydrogen bonding motif for forming extended assemblies

Oligoamide strands containing tertiary amide groups were found to share a basic structural motif that promotes the formation of H-bonded, chain- or tape-like supramolecular assemblies.

Ureidopyrimidinones incorporating a functionalizable p-aminophenyl electron-donating group at C-6

(Chemical Equation Presented) 2-Ureido-4-[1H]-pyrimidinones have been reported to dimerize via quadruple hydrogen bonding systems with dimerization constants >106 M-1 in CDCl3. The dimerization constant, Kdim, is dependent on the solvent as well as the ring-substituents present, where previously alkyl (e.g., R1 = Me) and aromatic moieties (e.g., R1 = p-NO2C 6H4, R1 = C6H2(OC 13H27)3) have been incorporated at the C-6 position. To assess the influence of alternative, functionalizable, electron-donating groups on the dimerization motif and tautomeric distribution of isomers, the synthesis of compounds possessing aminophenyl functionality at the C-6 position has been achieved. NMR spectroscopy chemical shift analysis revealed that compound 2 (R1 = p-NH2C6H 4, R2 = C6H13) existed as the 2-ureido-4-pyrimidinol dimeric DADA array in DMSO-d6, where a dimerization constant of 46 M-1 was determined. This is the first time that a ureidopyrimidinone quadruple hydrogen bonding DADA array has been observed in pure DMSO, a highly polar solvent. The azo-derivative 5 of compound 2 was prepared which also adopted the pyrimidin-4-ol form in DMSO-d6. Compounds 7, 10 and 11 were then synthesized containing a more hydrophilic PEG unit in the lateral chain and the tautomeric distributions were determined.

SUBSTITUTED ACETANILIDES AND BENZAMIDES FOR THE TREATMENT OF ASTHMA AND PULMONARY INFLAMMATION

Substituted acetanilide or benzamide compositions or formulations for delivery by aerosolization are described. The formulation contains an efficacious amount of acetanilide or benzamide compound able to inhibit inflammation in asthmatic lungs. Compounds of the invention are formulated in 5 ml solution of a quarter normal saline having pH between 5.0 and 7.0. The method for treatment of respiratory tract inflammation by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 μ, produced by nebulization or dry powder inhaler.

Prodrugs of etoposide and etoposide analogs

The present invention provides amphiphilic prodrugs comprising a therapeutic compound conjugated to an PEG-oligomer/polymer and methods for using said prodrugs to enable oral drug delivery and/or delivery of drugs across the blood brain barrier into the c