63888-93-7

Basic information

• Product Name: ethyl 2-(benzyloxy)benzoate
• CAS NO: 63888-93-7
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.2964
• Mol File: 63888-93-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 378.4°C at 760 mmHg
• Flash Point: 158.9°C
• Density: 1.121g/cm³
• Vapor Pressure: 6.3E-06mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: ethyl 2-(benzyloxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(benzyloxy)benzoate(63888-93-7)
• EPA Substance Registry System: ethyl 2-(benzyloxy)benzoate(63888-93-7)

Safety Data

• Hazardous Substances Data: 63888-93-7(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 64-17-5 ethanol 
• 14389-86-7 2-benzyloxybenzoic acid 
• 69-72-7 salicylic acid 

Downstream Products

• 1355235-17-4 N-(2-Acetyl-4-morpholinophenyl)-2-benzyloxybenzamide 
• 1355235-39-0 2-(2-benzyloxyphenyl)-6-morpholinoquinolin-4-one 
• 1355235-60-7 2-(2-hydroxyphenyl)-6-morpholinoquinolin-4-one 
• 4349-62-6 2-benzyloxybenzoyl chloride 
• 14389-86-7 2-benzyloxybenzoic acid 

Relevant articles and documents

Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters

An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.

Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice

Ginger is one of the most commonly used fresh herbs and spices. Enterotoxigenic Escherichia coli heat-labile enterotoxin (LT)-induced diarrhea is the leading cause of infant death in developing countries. In this study, we demonstrated that ginger significantly blocked the binding of LT to cell-surface receptor GM1, resulting in the inhibition of fluid accumulation in the closed ileal loops of mice. Biological-activity-guided searching for active components showed that zingerone (vanillylacetone) was the likely active constituent responsible for the antidiarrheal efficacy of ginger. Further analysis of chemically synthesized zingerone derivatives revealed that compound 31 (2-[(4-methoxybenzyl)oxy]benzoic acid) significantly suppressed LT-induced diarrhea in mice via an excellent surface complementarity with the B subunits of LT. In conclusion, our findings provide evidence that ginger and its derivatives may be effective herbal supplements for the clinical treatment of enterotoxigenic Escherichia coli diarrhea.

Hypolipidemic analogues of ethyl 4 benzyloxybenzoate

A series of compounds related to ethyl 4-benzyloxybenzoate was synthesized and evaluated for potential hypolipidemic activity in rats. Structure-activity relationships are discussed in terms of cholesterol-lowering activity together with effects on body weight gain and liver lipids. A number of the compounds inhibited cholesterol and free fatty acid biosynthesis from [1-14C]acetate in rat liver slices in vitro. Ethyl 4-benzyloxybenzoate, ethyl 4-benzyloxybenzoic acid, ethyl 4-p-bromobenzyloxybenzoate, and ethyl 4-o-methoxybenzyloxyphenyl acetate exhibited the most favorable spectrum of activity.