63897-00-7Relevant academic research and scientific papers
O-Benzoyl pyridine aldoxime and amidoxime derivatives: Novel efficient DNA photo-cleavage agents
Karamtzioti, Paraskevi,Papastergiou, Asterios,Stefanakis, John G.,Koumbis, Alexandros E.,Anastasiou, Ioanna,Koffa, Maria,Fylaktakidou, Konstantina C.
, p. 719 - 726 (2015)
O-Benzoyl derivatives of meta-, ortho- and para-pyridine aldoximes and amidoximes are novel efficient DNA photo-cleavage agents. In particular O-p-nitro-benzoyl derivatives 4, 8 and 15 were effective at concentrations as low as 1 μM. Both aldoximes and amidoximes were active under aerobic and anaerobic conditions, with a double-stranded to single-stranded DNA cleavage ratio of up to 1. These results give prospects for multiple applications, including phototherapeutic treatment of solid tumors. This journal is
