639010-93-8

Basic information

• Product Name: Propanoic acid, 2-methyl-3-phenoxy-, (2R)- (9CI)
• Synonyms: Propanoic acid, 2-methyl-3-phenoxy-, (2R)- (9CI)
• CAS NO: 639010-93-8
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.20048
• Product Categories: METHOXY
• Mol File: 639010-93-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 279.8±13.0 °C(Predicted)
• Appearance: /
• Density: 1.140±0.06 g/cm3(Predicted)
• PKA: 4.20±0.10(Predicted)
• CAS DataBase Reference: Propanoic acid, 2-methyl-3-phenoxy-, (2R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-methyl-3-phenoxy-, (2R)- (9CI)(639010-93-8)
• EPA Substance Registry System: Propanoic acid, 2-methyl-3-phenoxy-, (2R)- (9CI)(639010-93-8)

Safety Data

• Hazardous Substances Data: 639010-93-8(Hazardous Substances Data)

Upstream product

• 57295-21-3 2-Phenoxymethyl-acrylic acid 
• 108-95-2 phenol 
• 639010-91-6 (-)-(S)-2-methyl-3-phenoxy-1-propanol 

Relevant articles and documents

SPIROBENZYLAMINE-PHOSPHINE, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to a spirobenzylamine-phosphine, preparation method therefor and use thereof. The compound has a structure represented by formula (I), wherein n=0 to 3; R1, R2, R3, R4, R5, R6, R7, R8 and R9 having a value as defined in claim 1. Starting from the substituted 7-trifluoromesyloxy-7'-diarylphosphino-1, 1'-spiro-dihydroindene, the compound is synthesized in a two-step or three-step reactions. The new spirobenzylamine-phosphine is complexed with an iridium precursor and is subjected to ion exchange, to give an Iridium/spirobenzylamine-phosphine complex comprising various anions. The spiro benzyl amine-phosphine/Iridium complex according to the present invention may be used for catalyzing asymmetry hydrogenation of a variety of alpha-substituted acrylic acids, has high activity and enantio-selectivity, and has a good prospect of industrialization.

Enantioselective hydrogenation of α-substituted acrylic acids catalyzed by iridium complexes with chiral spiro aminophosphine ligands

Highly active: Iridium complexes with chiral spiro aminophosphine ligands were synthesized and applied as catalysts for the asymmetric hydrogenation of α-substituted acrylic acids (see scheme). The complexes were highly active catalysts, showing turnover frequencies of up to 6000 h-1, and catalyst loadings could be reduced to 0.01 mol %. Copyright