639091-52-4

Basic information

• Product Name: 6-[4-(thiophen-3-ylmethoxy)-phenoxy]-nicotinic acid methyl ester
• CAS NO: 639091-52-4
• Molecular Weight: 341.387
• Mol File: 639091-52-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-[4-(thiophen-3-ylmethoxy)-phenoxy]-nicotinic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[4-(thiophen-3-ylmethoxy)-phenoxy]-nicotinic acid methyl ester(639091-52-4)
• EPA Substance Registry System: 6-[4-(thiophen-3-ylmethoxy)-phenoxy]-nicotinic acid methyl ester(639091-52-4)

Safety Data

• Hazardous Substances Data: 639091-52-4(Hazardous Substances Data)

Upstream product

• 639091-45-5 methyl 6-(4-hydroxyphenoxy)nicotinate 
• 34846-44-1 3-Bromomethylthiophene 
• 153861-42-8 6-(4-hydroxyphenoxy)nicotinic acid 

Downstream Products

• 639091-54-6 6-{4-[(3-thienylbenzyl)oxy]phenoxy}nicotinic acid 

Relevant articles and documents

Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: A potent and orally bioavailable NCX inhibitor

Ca2+ overload in myocardial cells is responsible for arrhythmia. Sodium-calcium exchanger (NCX) inhibitors are more effective than sodium-hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca 2+ overload, because NCX inhibitors can directly inhibit the influx of Ca2+ into cells. NCX is an attractive target for the treatment of heart failure and ischemia-reperfusion. We have designed and synthesized a series of N-(2-aminopyridin-4-ylmethyl)nicotinamide derivatives, based on compound 5. We have discovered a novel NCX inhibitor (23h) with an IC 50 value of 0.12 μM against reverse NCX. The inhibitory activities of our NCX inhibitors against cytochrome P450 were also evaluated. The effects on heart failure and the pharmacokinetic profile of compound 23h are discussed.