63930-17-6

Basic information

• Product Name: BIS(3-FLUOROPHENYL)DISULFIDE
• Synonyms: 3,3'-DIFLUORO DIPHENYL DISULFIDE;BIS(3-FLUOROPHENYL)DISULFIDE;BIS(3-FLUOROPHENYL)DISULPHIDE;3,3-Difluorodiphenyl disulphide~3-Fluorophenyl disulphide;Bis(3-Fluorphenyl)Disulfide;3-Fluorophenyldisulfide;Bis(3-fluorophenyl)disulphide 97%;Bis(3-fluorophenyl)disulphide97%
• CAS NO: 63930-17-6
• Molecular Formula: C₁₂H₈F₂S₂
• Molecular Weight: 254.32
• Mol File: 63930-17-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 308℃
• Flash Point: >110°(230°F)
• Appearance: yellow or colorless liquid
• Density: 1.32
• Vapor Pressure: 0.00106mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: 2-8°C
• Sensitive: Stench
• BRN: 2530329
• CAS DataBase Reference: BIS(3-FLUOROPHENYL)DISULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(3-FLUOROPHENYL)DISULFIDE(63930-17-6)
• EPA Substance Registry System: BIS(3-FLUOROPHENYL)DISULFIDE(63930-17-6)

Safety Data

• Statements: 22
• Safety Statements: 23-36/37
• PackingGroup: III
• Hazardous Substances Data: 63930-17-6(Hazardous Substances Data)

Usage

General Description

Bis(3-fluorophenyl)disulfide is a chemical compound with a molecular formula of C12H8F2S2. It is characterized by having two 3-fluorophenyl groups linked by a disulfide bridge. BIS(3-FLUOROPHENYL)DISULFIDE falls under the category of organofluorides and organosulfides. Organofluorides are organic compounds that contain a carbon-fluorine bond, while organosulfides are organic compounds that contain carbon-sulfur bonds. This specific compound is generally used in research and industrial procedures as a reagent or building block in chemical synthesis. Information regarding its properties such as its melting point, boiling point, solubility, and toxicity might not be readily available, as it is not a common substance, but those would be assessed under controlled laboratory conditions.

InChI:InChI=1/C12H8F2S2/c13-9-3-1-5-11(7-9)15-16-12-6-2-4-10(14)8-12/h1-8H

Upstream product

• 2557-77-9 3-fluorothiophenol 
• 1996-38-9 3-fluorobenzenediazonium tetrafluoroborate 

Downstream Products

• 1314532-84-7 tert-butyl (3aS,4R,6S,6aR)-6-(2-(3-fluorophenylthio)propan-2-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ylcarbamate 
• 1314532-79-0 S-3-fluorophenyl 4-methylbenzenesulfonothioate 
• 1204677-76-8 1-(benzylsulfonyl)-3-fluorobenzene 
• 2402-01-9 1-fluoro-3-thiocyanatobenzene 
• 1374639-67-4 1,4-bis(3-fluorophenylthio)-2,3,5,6-tetrafluorobenzene 
• 1352121-35-7 N-((3-fluorophenylthio)methyl)-N-methylacetamide 
• 853685-38-8 3-(3-fluorophenyl)sulfanyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid amide 
• 1346164-90-6 3-(3-fluorophenylthio)-1-methyl-2-phenyl-1H-indole 
• 791642-77-8 4-phenyl-2-(3-fluoro-phenylsulfanyl)-phenol 
• 1313220-34-6 C₂₀H₁₆F₂S₂ 
• 1191950-74-9 3-((3-fluorophenyl)thio)-2-phenylbenzofuran 
• 137897-68-8 6-<(3-fluorophenyl)thio>-1-<(2-hydroxyethoxy)methyl>thymine 

Relevant articles and documents

Preparation method of symmetric disulfide bond-containing compound

The method comprises the following steps: adding a raw material and an oxidant to a reaction bottle containing a solvent; reacting 23W - 85W under the irradiation of 12 - 24h energy-saving lamps; and purifying the reaction product to obtain symmetrical disulfide bond-containing compounds. The raw material is mercaptan or thiophenol. The oxidizing agent is trichlorobromomethane, and the solvent is tetrahydrofuran. The method has the advantages of simple operation, high yield (70 - 90%), wide applicability, cheap and easily available raw materials, and provides a better way for the synthesis and production of symmetrical disulfide bond-containing compounds.

Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity

Diaryl disulfides and diaryl thiosulfonates were synthesized with the two phenyl rings of all compounds bearing identical halide substituents. Because of structural similarity to the potent antimitotic natural product combretastatin A-4 (CA-4), the compounds were examined for inhibition of tubulin polymerization, and the thiosulfonates were more active than the disulfides. The nine thiosulfonates had IC50 values ranging from 1.2 to 9.1 μM, as compared with 1.3 μM obtained with CA-4. The compounds thus ranged from equipotent with CA-4 to 7-fold less active. The nine disulfides had IC50 values ranging from 1.2 to 5.1 μM, as compared with 0.54 μM obtained with CA-4. The compounds thus ranged from less than half as active as CA-4 to over 9-fold less active. The most active members of each group, 2 g and 3c, in the assembly assay were modeled into the colchicine site. Compound 3c had significant hydrophobic interactions with β-tubulin residues CYS 241 and ALA 250, and its thiosulfonate bridge made a hydrogen bond with β-tubulin residue ASN 258. Compound 2 g had hydrophobic interactions with β-tubulin residues ALA 250, CYS 241 and ALA 254, but there was no significant interaction of the disulfide bridge with tubulin.

An Organodiselenide with Dual Mimic Function of Sulfhydryl Oxidases and Glutathione Peroxidases: Aerial Oxidation of Organothiols to Organodisulfides

A novel organodiselenide, which mimics sulfhydryl oxidases and glutathione peroxidase (GPx) enzymes for oxidation of thiols by oxygen and hydrogen peroxide, respectively, into disulfides has been presented. The developed catalyst oxidizes an array of organothiols into respective disulfides in practical yields by using aerial O2 to avoid any reagents/additives, base, and light source. The synthesized diselenide also catalyzes the reduction of hydrogen peroxide into water by following the GPx enzymatic catalytic cycle with a reduction rate of 49.65 ± 3.7 μM·min-1.