6398-72-7

Upstream product

• 98-88-4 benzoyl chloride 
• 2365-48-2 Methyl thioglycolate 
• 1665-64-1 methyl bis(thioacetate) 
• 10489-23-3 S-1-octyl benzothioate 
• 942-91-6 Carboxymethyl dithiobenzoate 
• 186581-53-3 diazomethane 
• 19547-47-8 (3,5-diphenyl-[1,4,2]oxathiazol-5-ylsulfanyl)-acetic acid 

Relevant academic research and scientific papers

Rhodium-catalyzed alkylthio exchange reaction of thioester and disulfide

The Wilkinson complex RhCl(PPh3)3 catalyzes equilibrating alkylthio exchange reaction of thioesters with disulfides. The treatment of a thioester and a dialkyl disulfide in refluxing diethyl ketone in the presence of RhCl(PPh3)3 (2.5 mol %) for 1.5 h gave an alkylthio exchanged thioester. The reaction of S-methyl ester was conducted shifting the equilibrium by removing volatile dimethyl disulfide.

High-Load, ROMP-Generated Oligomeric Bis-acid Chlorides: Design of Soluble and Insoluble Nucleophile Scavengers

(Equation presented) An efficient strategy for scavenging a host of nucleophiles utilizing an oligomeric bis-acid chloride (OBAC), generated from the ROM polymerization of trans-bicyclo[2.2.1]hept-5-ene-2,3-dicarbonyl dichloride, is described. The reactivity and high load of the OBAC reagent is exploited in the scavenging of amines, alcohols, and thiols that are present in excess following a common benzoylation event. Following the scavenging event, these oligomers can be precipitated with EtOAc and filtered (SiO2), leaving benzoylated nucleophiles in excellent yield and purity.