639814-85-0Relevant academic research and scientific papers
Second generation of fucose-based DC-SIGN ligands: Affinity improvement and specificity versus Langerin
Andreini, Manuel,Doknic, Daniela,Sutkeviciute, Ieva,Reina, Jose J.,Duan, Janxin,Chabrol, Eric,Thepaut, Michel,Moroni, Elisabetta,Doro, Fabio,Belvisi, Laura,Weiser, Joerg,Rojo, Javier,Fieschi, Franck,Bernardi, Anna
supporting information; experimental part, p. 5778 - 5786 (2011/10/02)
DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (LeX). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection.
Investigation of ligand loading and asymmetric amplification in CHAOx-catalyzed asymmetric diethylzinc additions
Wipf, Peter,Pierce, Joshua G.,Wang, Xiaodong
, p. 3605 - 3611 (2007/10/03)
The recently developed (cyclohexylsulfonylamino)oxazoline (CHAOx) ligand was found to provide high ee's and consistent reaction rates in the asymmetric diethylzinc addition to benzaldehyde over a remarkably large loading range of 0.05-10 mol%. Turnover numbers of 1000-2000 can be explained by the absence of a nonlinear effect and the formation of a catalytically active monomer complex. Substituents at the nitrogen donor atoms of the bidentate ligand prevent zinc-complex dimerization.
