141435-12-3Relevant academic research and scientific papers
Asymmetric Diels-Alder Reaction Catalyzed by a Chiral Titanium Reagent
Narasaka, Koichi,Iwasawa, Nobuharu,Inoue, Masayuki,Yamada, Tohru,Nakashima, Masako,Sugimori, Jun
, p. 5340 - 5345 (1989)
A highly enantioselective Diels-Alder reaction has been developed by employing a chiral titanium reagent generated in situ from dichlorodiisopropoxytitanium and the chiral diol 1d, which is easily derived from tartaric acid.With a catalytic amount of the
Investigation of ligand loading and asymmetric amplification in CHAOx-catalyzed asymmetric diethylzinc additions
Wipf, Peter,Pierce, Joshua G.,Wang, Xiaodong
, p. 3605 - 3611 (2007/10/03)
The recently developed (cyclohexylsulfonylamino)oxazoline (CHAOx) ligand was found to provide high ee's and consistent reaction rates in the asymmetric diethylzinc addition to benzaldehyde over a remarkably large loading range of 0.05-10 mol%. Turnover numbers of 1000-2000 can be explained by the absence of a nonlinear effect and the formation of a catalytically active monomer complex. Substituents at the nitrogen donor atoms of the bidentate ligand prevent zinc-complex dimerization.
Asymmetric Diels-Alder Reaction by the Use of a Chiral Titanium Catalyst with Molecular Sieves 4A. Remarkable Solvent Effect on the Enantioselectivity
Narasaka, Koichi,Inoue, Masayuki,Yamada, Tohru,Sugimori, Jun,Iwasawa, Nobuharu
, p. 2409 - 2412 (2007/10/02)
A remarkable effect of solvent on the enantioselectivity was observed in the asymmetric Diels-Alder reaction of 3-(2-alkenoyl)-1,3-oxazolidin-2-ones and dienes catalyzed by a chiral titanium reagent, and the Diels-Alder adducts were obtained in high enant
