64-65-3

Basic information

• Product Name: 3-ETHYL-3-METHYLGLUTARIMIDE
• Synonyms: 2,6-Piperidinedione, 4-ethyl-4-methyl-;3,3-Methylethylilotarimide;2,6-DIOXO-4-METHYL-4-ETHYLPIPERIDINE;NP-13;BEMEGRIDE, 99+%;4-Ethyl-4-methylpiperidine -2,6-dione;β,β-Methylethylglutarimide;3-ethyl-3-methyl-glutarimid
• CAS NO: 64-65-3
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.19
• EINECS: 200-588-0
• Mol File: 64-65-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 126-127 °C(lit.)
• Boiling Point: 279°C (rough estimate)
• Flash Point: 125.8oC
• Appearance: white/powder
• Density: 1.1174 (rough estimate)
• Vapor Pressure: 0.00344mmHg at 25°C
• Refractive Index: 1.4860 (estimate)
• Storage Temp.: −20°C
• PKA: pKa 11.7 (Uncertain)
• Water Solubility: Soluble in water
• Merck: 14,1027
• CAS DataBase Reference: 3-ETHYL-3-METHYLGLUTARIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ETHYL-3-METHYLGLUTARIMIDE(64-65-3)
• EPA Substance Registry System: 3-ETHYL-3-METHYLGLUTARIMIDE(64-65-3)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 22-36/37/39-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: MA4550000
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 64-65-3(Hazardous Substances Data)

Usage

Uses

CNS stimulant;GABA antagonist

Brand name

Megimide (Abbott).

General Description

White crystalline solid. Sublimes at 212°F and 200 mm pressure.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

3-ETHYL-3-METHYLGLUTARIMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition it emits toxic fumes.

Fire Hazard

Flash point data for 3-ETHYL-3-METHYLGLUTARIMIDE are not available. 3-ETHYL-3-METHYLGLUTARIMIDE is probably not flammable.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, intramuscular, subcutaneous, and parented routes. Human systemic effects by ingestion: wakefulness, hallucinations, distorted perceptions, toxic psychosis. An analeptic, central nervous system stimulant; used to counteract barbiturate poisoning. When heated to decomposition it emits toxic fumes of NOx.

InChI:InChI=1/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11)

Upstream product

• 6970-57-6 3-ethyl-3-methylglutaric anhydride 
• 57-13-6 urea 
• 872821-77-7 4-ethyl-5-cyano-2-imino-4-methyl-6-oxo-piperidine-3-carboxylic acid amide 
• 5345-01-7 3-ethyl-3-methylglutaric acid 
• 77287-34-4 formamide 

Downstream Products

• 104175-94-2 4-ethyl-1-[4-(α-hydroxy-benzhydryl)-piperidinomethyl]-4-methyl-piperidine-2,6-dione 
• 4045-31-2 4-ethyl-4-methylpiperidine 
• 15077-29-9 3-Methyl-3-ethyl-1.5-amylenglykol-bis-p-nitrobenzoat 
• 63515-89-9 1-benzyl-4-ethyl-4-methyl-piperidine-2,6-dione 
• 94383-05-8 DL-3-(4-Methyl-4-ethyl-2,6-dioxo-piperidinomethyl)-4-methyl-5-phenyl-oxazolidin 
• 94383-05-8 4-ethyl-4-methyl-1-(4r-methyl-5t-phenyl-oxazolidin-3-ylmethyl)-piperidine-2,6-dione 
• 94383-05-8 L-3-(4-Methyl-4-ethyl-2,6-dioxo-piperidinomethyl)-4-methyl-5-phenyl-oxazolidin 
• 94383-05-8 4-ethyl-4-methyl-1-((4R)-4r-methyl-5c-phenyl-oxazolidin-3-ylmethyl)-piperidine-2,6-dione 
• 103990-74-5 3-(4-Methyl-4-ethyl-2,6-dioxo-piperidinomethyl)-4-methyl-5-(4-methoxy-phenyl)-oxazolidin 

Relevant articles and documents

AMIDOALKYLPIPERAZINYL DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES

The invention relates to novel amidoalkylpiperazinyl derivatives of tricyclic heterocyclic systems of general formula (I), wherein Z represents -NH- and X represents -S-, or Z represents -S- and X represents >C=C1 represents H or -CH3, R6 and R7 both represent H, n is an integer from 0 to 4 inclusive, G represents a cyclic amide or imide moiety, and optical isomers, geometric isomers, and pharmaceutically acceptable salts thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders.