640-79-9Relevant articles and documents
Glycocholic acid ester, preparation method thereof and preparation method of glycocholic acid
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, (2021/02/24)
The invention provides a preparation method of glycocholic acid ester, glycocholic acid ester and a preparation method of glycocholic acid, according to the preparation method of glycocholic acid ester, an aza-carbene derivative is used as a condensation reagent, and synthesis of glycocholic acid ester can be efficiently completed through a one-pot method in a wide solvent range. The yield can reach 90% or above, the reaction conditions are mild, and the method can be suitable for preparation of most glycocholic acid esters and can be better suitable for amplification and industrial production.
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts
Venturoni, Francesco,Gioiello, Antimo,Sardella, Roccaldo,Natalini, Benedetto,Pellicciari, Roberto
experimental part, p. 4109 - 4115 (2012/06/15)
A multi-gram scale protocol for the N-acyl amidation of bile acids with glycine and taurine has been successfully developed under continuous flow processing conditions. Selecting ursodeoxycholic acid (UDCA) as the model compound and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) as the condensing agent, a modular mesoreactor assisted flow set-up was employed to significantly speed up the optimization of the reaction conditions and the flow scale-up synthesis. The results in terms of yield, in line purification, analysis, and implemented flow set-up for the reaction optimization and large scale production are reported and discussed.
An improved procedure for the synthesis of glycine and taurine conjugates of bile acids
Tserng,Hachey,Klein
, p. 404 - 407 (2007/10/06)
Glycine and taurine conjugates of 5β cholanic acids have been synthesized using improved procedures based on the peptide coupling reagent, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The conjugates are obtained in chromatographically pure form in yields higher than 90%. The use of this procedure in the large scale preparation of choly[1,2 13C2]glycine is described.
