6401-02-1

Basic information

• Product Name: 2,2,3,3-TETRAFLUOROPROPYL TRIFLUOROMETHANESULFONATE
• Synonyms: 2,2,3,3-TETRAFLUOROPROPYL TRIFLUOROMETHANESULFONATE;2,2,3,3-TETRAFLUOROPROYL TRIFLUOROMETHANESULFONATE;1H,1H,3H-TETRAFLUOROPROPYL TRIFLATE;2,2,3,3-Tetrafluoropropyl trifluoromethane sulphonate 97%;2,2,3,3-Tetrafluoropropyltrifluoromethanesulphonate97%;2,2,3,3-Tetrafluoroprop-1-yl triflate, 2,2,3,3-Tetrafluoropropyl trifluoromethanesulphonate;2,2,3,3-Tetrafluoroprop-1-yl trifluoromethanesulphonate 97%;2,2,3,3-Tetrafluoroprop-1-yltrifluoromethanesulphonate97%
• CAS NO: 6401-02-1
• Molecular Formula: C₄H₃F₇O₃S
• Molecular Weight: 264.12
• Mol File: 6401-02-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 114-118 °C
• Boiling Point: 122-125/737mm
• Flash Point: 64.4°C
• Appearance: /
• Density: 1.644g/cm³
• Vapor Pressure: 1.09mmHg at 25°C
• Refractive Index: 1.3203
• CAS DataBase Reference: 2,2,3,3-TETRAFLUOROPROPYL TRIFLUOROMETHANESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,3,3-TETRAFLUOROPROPYL TRIFLUOROMETHANESULFONATE(6401-02-1)
• EPA Substance Registry System: 2,2,3,3-TETRAFLUOROPROPYL TRIFLUOROMETHANESULFONATE(6401-02-1)

Safety Data

• Hazard Codes: C,Xi,T
• HazardClass: TOXIC, CORROSIVE
• Hazardous Substances Data: 6401-02-1(Hazardous Substances Data)

Usage

General Description

2,2,3,3-Tetrafluoropropyl trifluoromethanesulfonate is a chemical compound with the molecular formula C4H3F7O3S. It is commonly referred to as TFPOTf and is known for its use as a fluorinating reagent in organic synthesis. TFPOTf is a colorless liquid that is highly reactive due to the presence of the trifluoromethanesulfonyl functional group, making it a strong and selective fluorination reagent. It is commonly used in the pharmaceutical industry for the introduction of fluorine atoms into organic compounds, as well as in the preparation of specialty chemicals. Additionally, TFPOTf is also used in the field of materials science for the modification of surfaces and polymers, and in the field of agrochemicals for the synthesis of new bioactive compounds. Overall, 2,2,3,3-Tetrafluoropropyl trifluoromethanesulfonate is a versatile and important chemical compound with a range of applications in various industries.

InChI:InChI=1/C4H3F7O3S/c5-2(6)3(7,8)1-15(12,13)14-4(9,10)11/h2H,1H2

Upstream product

• 76-37-9 2,2,3,3-tetrafluoropropanol 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 335-05-7 Trifluoromethanesulfonyl fluoride 
• 121-44-8 triethylamine 
• 421-83-0 trifluoromethane sulfonyl chloride 

Downstream Products

• 82914-35-0 1,1,2,2-tetrafluoro-3-(2,2,3,3-tetrafluoropropoxy)propane 
• 1174186-20-9 5-amino-6-(3-chloro-2-fluoro-5-trifluoromethyphenyl)-2,3-dihydro-3-imino-2-(2,2,3,3-tetrafluoropropyl)-1,2,4-triazine trifluoromethanesulphonate 

Relevant articles and documents

Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure

The first-in-class soluble guanylate cyclase (sGC) stimulator riociguat was recently introduced as a novel treatment option for pulmonary hypertension. Despite its outstanding pharmacological profile, application of riociguat in other cardiovascular indications is limited by its short half-life, necessitating a three times daily dosing regimen. In our efforts to further optimize the compound class, we have uncovered interesting structure-Activity relationships and were able to decrease oxidative metabolism significantly. These studies resulting in the discovery of once daily sGC stimulator vericiguat (compound 24, BAY 1021189), currently in phase 3 trials for chronic heart failure, are now reported.

METHODS OF MAKING FLUORINATED ETHERS, FLUORINATED ETHERS, AND USES THEREOF

A method of making a fluorinated ether includes combining, in a polar aprotic solvent: a fluorinated alcohol represented by the formula X—Rf1CH2OH, and a fluorinated sulfonate ester represented by the formula Rf2CH2OS(═O)2Rf3, and base; and obtaining a fluorinated ether represented by the formula Y—Rf1CH2OCH2Rf2—Y. Rf1 is selected from perfluorinated C1-C10 alkylene groups having from 1 to 10 carbon atoms and partially fluorinated C1-C10 alkylene groups, and derivatives thereof having catenated heteroatom(s). X represents H, F, or an HOCH2— group. Rf2 is selected from perfluorinated C1-C10 alkyl groups and partially fluorinated C1-C10 alkyl groups, and derivatives thereof having catenated heteroatom(s). Rf3 is a C1-C4 alkyl group. Y represents H, F, or an Rf2CH2OCH2— group. A variant method, useful for preparing symmetric fluorinated ethers, is also disclosed. The present disclosure also provides fluorinated ethers preparable according to the methods. Use of fluorinated ethers in various applications is also disclosed.

NITRILE COMPOUND AND ITS USE IN PEST CONTROL

The present invention provides a nitrile compound represented by the formula (I): wherein R represents C1-C4 fluoroalkyl, Q represents halogen, C1-C11 alkyl optionally substituted with halogen, C2-C6 alkenyl group optionally substituted with halogen, C2-C6 alkynyl optionally substituted with halogen, C3-C7 cycloalkyl optionally substituted with halogen or (C3-C7 cycloalkyl optionally substituted with halogen)C1-C4 alkyl, which has excellent control effect against pests.