76-37-9

Usage

Uses

Used in Optical Data Storage Industry:
Tetrafluoro-1-propanol is used as a dye solvent in the CD-R(W) and DVD-R(W) industry. Its unique properties, such as low surface tension and high solubility, make it an ideal choice for this application, ensuring the proper functioning and performance of optical data storage devices.
Used in Textile Treatment Industry:
Tetrafluoro-1-propanol is used as a textile treatment agent. Its properties, such as high chemical stability and low surface tension, enable it to provide various benefits to textiles, including improved water and oil repellency, stain resistance, and easy cleaning.
Used in Pharmaceutical Industry:
Tetrafluoro-1-propanol is used in the production of pharmaceuticals. Its unique properties, such as high solubility in water and various solvents, make it a valuable ingredient in the formulation of drugs, particularly those requiring solubility enhancement or specific chemical stability.
Used as a Replacement for Freon 22 Detergent:
Tetrafluoro-1-propanol is an ideal replacement for Freon 22 detergent due to its environmentally friendly nature and similar properties. It can be used in various applications where Freon 22 was previously used, such as in cleaning agents and degreasers, without causing harm to the environment or contributing to the depletion of the ozone layer.

Purification Methods

Tetrafluoro-1-propanol (450mL) is added to a solution of 2.25g of NaHSO3 in 90mL of water, shaken vigorously and set aside for 24hours. The fraction distilling at or above 99o is refluxed for 4hours with 5-6g of KOH and rapidly distilled, followed by a final fractional distillation. [Kosower & Wu J Am Chem Soc 83 3142 1961.] Alternatively, shake the alcohol with alumina for 24hours, dry it overnight with anhydrous K2CO3 and distil it, taking the middle fraction (b 107-108o). [Beilstein 1 IV 2438.]

InChI:InChI=1S/C3H4F4O/c4-2(5)3(6,7)1-8/h2,8H,1H2

Synthetic route

phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester (65611-25-8) + triethylamine (121-44-8) → 2,2,3,3-tetrafluoropropanol (76-37-9) + triethylammonium hydrogen 1H,1H,3H-tetrafluoropropyl phosphite

Conditions	Yield
With water for 1h; Ambient temperature;	A 96.4% B 88.6%

3,5-Bis-(1,1,2,2-tetrafluoro-ethyl)-2,2,2-tris-(2,2,3,3-tetrafluoro-propoxy)-2λ5-[1,4,2]dioxaphospholane → 2,2,3,3-tetrafluoropropanol (76-37-9) + 2,2,3,3-tetrafluoropropionaldehyde (756-04-7) + (2,2,3,3-Tetrafluoro-1-hydroxy-propyl)-phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester

Conditions	Yield
With water In acetone at 20℃; for 20h;	A n/a B n/a C 95%

chloral hydrate (302-17-0) + di(1,1,3-trihydrotetrafluoropropyl)phenyl phosphonite (87651-42-1) → 2,2,3,3-tetrafluoropropanol (76-37-9) + (1,1,3-trihydrotetrafluoropropyl) (1-hydroxy-2,2,2-trichloroethyl)phenylphosphinate (1235818-80-0)

Conditions	Yield
In benzene at 30 - 40℃; for 12h; Abramov reaction; Inert atmosphere;	A n/a B 95%

2,2,3,3,4,4,5,5-octafluorovaleraldehyde (2648-47-7) + tris(2,2,3,3-tetrafluoropropyl)phosphite (2241-68-1) → 2,2,3,3-tetrafluoropropanol (76-37-9) + bis(2,2,3,3-tetrafluoropropyl) (1H,5H-octafluoro-1-hydroxypentyl)phosphonate

Conditions	Yield
In benzene at 20 - 25℃; for 2h;	A n/a B 92%

pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane (71879-02-2) + p-Chlorothiophenol (106-54-7) → phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester) (563-10-0) + 2,2,3,3-tetrafluoropropanol (76-37-9) + 1-Chloro-4-(2,2,3,3-tetrafluoro-propylsulfanyl)-benzene

Conditions	Yield
at 150℃; for 4h;	A n/a B n/a C 72%

chloral hydrate (302-17-0) + C7H9F8O2P → 2,2,3,3-tetrafluoropropanol (76-37-9) + O-(1,1,3-trihydrotetrafluoropropyl)-(1-hydroxy-2,2,2-trichloroethyl)methylphosphinate (111257-11-5) + (1-hydroxy-2,2,2-trichloroethyl)methylphosphinic acid

Conditions	Yield
In benzene for 12h; Heating;	A n/a B 70% C n/a

pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane (71879-02-2) + para-bromobenzenethiol (106-53-6) → phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester) (563-10-0) + 2,2,3,3-tetrafluoropropanol (76-37-9) + 1-Bromo-4-(2,2,3,3-tetrafluoro-propylsulfanyl)-benzene

Conditions	Yield
at 150℃; for 4h;	A n/a B n/a C 70%

pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane (71879-02-2) + thiophenol (108-98-5) → phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester) (563-10-0) + 2,2,3,3-tetrafluoropropanol (76-37-9) + 2,2,3,3-tetrafluoropropylphenyl sulfide

Conditions	Yield
at 150℃; for 4h;	A n/a B n/a C 63.5%

pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane (71879-02-2) + para-thiocresol (106-45-6) → phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester) (563-10-0) + 2,2,3,3-tetrafluoropropanol (76-37-9) + 1-Methyl-4-(2,2,3,3-tetrafluoro-propylsulfanyl)-benzene

Conditions	Yield
at 150℃; for 4h;	A n/a B n/a C 60%

2,2,2-Tris-(2,2,3,3-tetrafluoro-propoxy)-3,5-bis-trifluoromethyl-2λ5-[1,4,2]dioxaphospholane → 2,2,3,3-tetrafluoropropanol (76-37-9) + 2,2,2-Trifluoroacetaldehyde (75-90-1) + (2,2,2-Trifluoro-1-hydroxy-ethyl)-phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester (88332-81-4)

Conditions	Yield
With water In acetone at 20℃; for 20h;	A n/a B n/a C 56%

2[(3,3,2,2-tetrafluoropropoxy)methyl]thiirane (1137575-85-9) → 2,2,3,3-tetrafluoropropanol (76-37-9) + 3-(2,2,3,3-tetrafluoropropoxy)-1-propene (681-68-5) + C6H8F4O

Conditions	Yield
at 210 - 215℃;	A n/a B 51% C n/a

methanol (67-56-1) + polytetrafluoroethylene (116-14-3) → 2,2,3,3-tetrafluoropropanol (76-37-9)

Conditions	Yield
With di-tert-butyl peroxide
With di-tert-butyl peroxide at 125℃; for 15.5h; Product distribution / selectivity;
With di-tert-butyl peroxide; calcium oxide at 125℃; for 20h; Product distribution / selectivity;

methanol (67-56-1) + polytetrafluoroethylene (116-14-3) → 2,2,3,3-tetrafluoropropanol (76-37-9) + 2,2,3,3,4,4,5,5-octafluoropentan-1-ol (355-80-6)

Conditions	Yield
With dibenzoyl peroxide at -30℃; for 6h; Yields of byproduct given;	A 12.3 g B n/a
With dibenzoyl peroxide at -30℃; for 6h; Yield given;	A 12.3 g B n/a

bis(1,1,3-trihydroperfluoropropyl) hydrogen phosphate (358-33-8) → phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester) (563-10-0) + 2,2,3,3-tetrafluoropropanol (76-37-9)

Conditions	Yield
Heating;	A 3.4 g B 0.7 g

pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane (71879-02-2) + thiophenol (108-98-5) → 2,2,3,3-tetrafluoropropanol (76-37-9) + C18H17F16O4PS (80587-03-7)

pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane (71879-02-2) + para-bromobenzenethiol (106-53-6) → 2,2,3,3-tetrafluoropropanol (76-37-9) + C18H16BrF16O4PS

C12H12F16O4Te (85878-21-3) → 2,2,3,3-tetrafluoropropanol (76-37-9)

Conditions	Yield
With hydrogenchloride In hexane; benzene

C20H25F20NO5P(1-)*C5H11N*H(1+) → phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester) (563-10-0) + 2,2,3,3-tetrafluoropropanol (76-37-9) + bis(2,2,3,3-tetrafluoropropyl) piperidinophosphonate + 1-(2,2,3,3-tetrafluoropropyl)piperidine (91461-54-0)

Conditions	Yield
at 150℃; for 15h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
at 150℃; for 15h; Yield given. Yields of byproduct given;

C19H23F20NO6P(1-)*C4H9NO*H(1+) → morpholine (110-91-8) + bis(2,2,3,3-tetrafluoropropyl) morpholinophosphonate (71878-96-1) + 2,2,3,3-tetrafluoropropanol (76-37-9) + 4-(2,2,3,3-tetrafluoropropyl)morpholine (343331-58-8)

Conditions	Yield
at 150℃; for 15h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
at 150℃; for 15h; Yield given. Yields of byproduct given;

pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane (71879-02-2) + para-thiocresol (106-45-6) → 2,2,3,3-tetrafluoropropanol (76-37-9) + C19H19F16O4PS

pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane (71879-02-2) + p-Chlorothiophenol (106-54-7) → 2,2,3,3-tetrafluoropropanol (76-37-9) + C18H16ClF16O4PS

polytetrafluoroethylene (116-14-3) + carbon monoxide → 2,2,3,3-tetrafluoropropanol (76-37-9)

Conditions	Yield
With dicobalt octacarbonyl; hydrogen at 150℃; under 110326 Torr;

C3H3F4O2N → 2,2,3,3-tetrafluoropropanol (76-37-9)

Conditions	Yield
With nitric acid Kinetics; Equilibrium constant; Further Variations:; Temperatures; Pressures;

1-(2,2,3,3-tetrafluoropropoxy)-perfluoroindan-1-yl cation → 2,2,3,3-tetrafluoropropanol (76-37-9) + perfluoroindane (1736-47-6) + octafluoro-1-indanone (58161-61-8)

Conditions	Yield
With hydrogenchloride

polytetrafluoroethylene (116-14-3) → 2,2,3,3-tetrafluoropropanol (76-37-9)

Conditions	Yield
With di-tert-butyl peroxide In methanol

chloral hydrate (302-17-0) + tris(2,2,3,3-tetrafluoropropyl)phosphite (2241-68-1) → 2,2,3,3-tetrafluoropropanol (76-37-9) + (2,2,2-trichloro-1-hydroxy-ethyl)-phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester (65611-19-0)

Conditions	Yield
Abramov reaction;

chloral hydrate (302-17-0) + C7H9F8O2P → 2,2,3,3-tetrafluoropropanol (76-37-9) + O-(1,1,3-trihydrotetrafluoropropyl)-(1-hydroxy-2,2,2-trichloroethyl)methylphosphinate (111257-11-5)

Conditions	Yield
Abramov reaction;

methyl 2,2,3,3-tetrafluoropropionate (1893-38-5) → 2,2,3,3-tetrafluoropropanol (76-37-9) + 2,2,3,3-Tetrafluoro-1-methoxy-propan-1-ol

Conditions	Yield
With C28H29ClNOP2Ru; hydrogen; sodium methylate In methanol at 36℃; under 3750.38 Torr; Autoclave;

2,2,3,3-tetrafluoropropanol (76-37-9) + 2-chloro-2,2-diphenyl-3,5-bis(1,1,2,2-tetrafluoroethyl)-1,4,2-dioxaphospholane (97108-40-2) → 2,2-Diphenyl-3,5-bis-(1,1,2,2-tetrafluoro-ethyl)-2-(2,2,3,3-tetrafluoro-propoxy)-2λ5-[1,4,2]dioxaphospholane

Conditions	Yield
With triethylamine In diethyl ether for 1h;	100%

α-isocyanatomethylmethyldimethoxysilane + 2,2,3,3-tetrafluoropropanol (76-37-9) → N-[dimethoxy(methyl)silylmethyl]carbamic acid-2,2,3,3-tetrafluoropropyl ester

Conditions	Yield
With dibutyltin dilaurate at 50 - 70℃; for 0.5h;	100%

6-bromo-pyridin-3-ol (55717-45-8) + 2,2,3,3-tetrafluoropropanol (76-37-9) → 2-bromo-5-(2,2,3,3-tetrafluoropropoxy)pyridine (1609098-11-4)

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 1h;	100%

perfluoropropylene (116-15-4) + 2,2,3,3-tetrafluoropropanol (76-37-9) → 1,1,1,2,3,3-hexafluoro-3-(2,2,3,3-tetrafluoropropoxy)propane (65064-78-0)

Conditions	Yield
With potassium hydroxide In water at 50 - 60℃; under 3000.3 - 3750.38 Torr; Inert atmosphere; Autoclave;	99.8%
With potassium hydroxide at 20 - 40℃;	87%
With potassium hydroxide
With potassium hydroxide In acetonitrile cooling;

Vinylidene fluoride (75-38-7) + 2,2,3,3-tetrafluoropropanol (76-37-9) → C5H6F6O (1201897-09-7)

Conditions	Yield
With potassium hydroxide In water at 75 - 80℃; under 6000.6 Torr; Inert atmosphere; Autoclave;	99.8%

2,2,3,3-tetrafluoropropanol (76-37-9) + carbonic acid dimethyl ester (616-38-6) → bis(2,2,3,3-tetrafluoropropyl) carbonate (1422-70-4)

Conditions	Yield
With sodium carbonate at 60 - 100℃; for 4h;	99.2%

2,2,3,3-tetrafluoropropanol (76-37-9) + (1,2,3,4,5,6-Hexachloro-2,3,4,5,6-pentafluoro-cyclohexyl)-[2-(2,2,3,3-tetrafluoro-propoxy)-2λ5-benzo[1,3,2]dioxaphosphol-2-ylidene]-amine (124842-01-9) → 2,2-bis(2,2,3,3-tetrafluoropropoxy)-2-(2,3,4,5,6-pentachloro-2,3,4,5,6-pentafluorocyclohexylideneamino)-1,3,2-benzodioxaphosphole (140476-65-9)

Conditions	Yield
With triethylamine In diethyl ether for 20h;	99%

1,1,1,3,3,3-hexachloro-propan-2-one (116-16-5) + 2,2,3,3-tetrafluoropropanol (76-37-9) → chloroform (67-66-3) + bis(2,2,3,3-tetrafluoropropyl) carbonate (1422-70-4)

Conditions	Yield
With potassium fluoride; zirconium(IV) oxide at 140℃; for 10h; Product distribution / selectivity; pressure tight reactor;	A 99% B 99%

2,2,3,3-tetrafluoropropanol (76-37-9) → O,O-bis(1,1,3-trihydroperfluoropropyl) hydrogen dithiophosphate (87992-83-4)

Conditions	Yield
With tetraphosphorus decasulfide at 150 - 170℃; for 45h;	98.7%
With tetraphosphorus decasulfide; triethylamine for 2h; Heating;	57%

polytetrafluoroethylene (116-14-3) + 2,2,3,3-tetrafluoropropanol (76-37-9) → 1,1,2,2-tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)propane (16627-68-2)

Conditions	Yield
With potassium hydroxide In water at 75 - 95℃; under 5625.56 - 6000.6 Torr; for 8.5h; Product distribution / selectivity; Inert atmosphere; Autoclave;	98.5%
With sodium In 1,4-dioxane
With potassium hydroxide In N,N-dimethyl-formamide
With potassium hydroxide In water at 20 - 95℃; under 750.075 - 6000.6 Torr; Product distribution / selectivity; Inert atmosphere; Industry scale; Autoclave;

2,2,3,3-tetrafluoropropanol (76-37-9) + Chlorotrifluoroethylene (79-38-9) → 3-(2-Chloro-1,1,2-trifluoro-ethoxy)-1,1,2,2-tetrafluoro-propane (65064-83-7)

Conditions	Yield
With potassium hydroxide In water at 75 - 85℃; under 3000.3 Torr; Inert atmosphere; Autoclave;	98%
With potassium hydroxide In N,N-dimethyl-formamide

2,2,3,3-tetrafluoropropanol (76-37-9) + 4,5-benzo-1,3,2-dioxaphosphol-2-yl 2,2,2-trifluoroacetate (85233-01-8) → 2-(2,2,3,3-tetrafluoropropoxy)-4,5-benzo-1,3,2-dioxaphospholane (88399-68-2) + trifluoroacetic acid (76-05-1)

Conditions	Yield
	A 98% B n/a

2,2,3,3-tetrafluoropropanol (76-37-9) + tris(2,2,3,3-tetrafluoropropyl)phosphite (2241-68-1) + benzenesulfenyl chloride (931-59-9) → C18H17F16O4PS (80587-03-7)

Conditions	Yield
With triethylamine In diethyl ether; dichloromethane at -50 - 20℃; for 1h;	98%

2,2,3,3-tetrafluoropropanol (76-37-9) + 3-[(chlorosulfinyl)oxy]-1,1,2,2-tetrafluoropropane (110920-07-5) → 1,1,2,2-tetrafluoro-3-(2,2,3,3-tetrafluoropropoxy)propane

Conditions	Yield
With N,N-dimethyl-formamide In chloroform at -10 - 20℃;	98%
With N,N-dimethyl-formamide at 25℃; Kinetics; Temperature;

2,2,3,3-tetrafluoropropanol (76-37-9) + carbon monoxide (201230-82-2) + n-decanoyl chloride (112-13-0) → C17H24F8O4

Conditions	Yield
Stage #1: carbon monoxide; n-decanoyl chloride With 2AlBr3*CBr4 at -20℃; under 735.576 Torr; for 1.45h; Stage #2: 2,2,3,3-tetrafluoropropanol at -20℃; under 735.576 Torr; for 2h; regioselective reaction;	98%

2,2,3,3-tetrafluoropropanol (76-37-9) + p-toluenesulfonyl chloride (98-59-9) → p-toluenesulfonic acid-2,2,3,3-tetrafluoropropyl ester (786-31-2)

Conditions	Yield
With triethylamine In dichloromethane for 3h; Ambient temperature;	97%
With triethylamine at 20℃; for 7h;	94%
With potassium hydroxide In benzene at 80℃; for 1h;	87%

1,1,1,3,3,3-hexachloro-propan-2-one (116-16-5) + 2,2,3,3-tetrafluoropropanol (76-37-9) → bis(2,2,3,3-tetrafluoropropyl) carbonate (1422-70-4)

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluoropropanol With Tetraethylene glycol dimethyl ether; potassium carbonate at 10 - 30℃; Stage #2: 1,1,1,3,3,3-hexachloro-propan-2-one at 30 - 70℃; Reagent/catalyst;	97%
With potassium fluoride at 100℃; for 10h;	100 g

2,2,3,3-tetrafluoropropanol (76-37-9) + 1-dimethylosiloxy-3,5,7,9,11,13,15-heptacyclohexylpentacyclo[9.5.113,9.15,15.17,13]octasiloxane → 1-(dimethyl(2,2,3,3-tetrafluoropropoxy)siloxy)-3,5,7,9,11,13,15-hepta(isobutyl)pentacyclo[9.5.1.13,9.15,15.17,13]octasiloxane

Conditions	Yield
With palladium on activated charcoal In tetrahydrofuran at 65℃; for 48h; Schlenk technique; Inert atmosphere;	97%

3-diazo-1-methyl-1,3-dihydro-indol-2-one (3265-14-3) + 2,2,3,3-tetrafluoropropanol (76-37-9) → 1-methyl-3-(2,2,3,3-tetrafluoropropoxy)indolin-2-one

Conditions	Yield
In dichloromethane at 25℃; for 24h; Irradiation;	97%

2,2,3,3-tetrafluoropropanol (76-37-9) → phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester) (563-10-0)

Conditions	Yield
With magnesium sulfate; trichlorophosphate at 60 - 120℃;	96%
With lithium chloride; trichlorophosphate for 2.5h; bath temperature 160 deg C;	91.6%
With phosphorus pentachloride at 20℃; for 12h;	66%

2,2,3,3-tetrafluoropropanol (76-37-9) → bis[(2,2,3,3-tetrafluoropropoxy)sulfonyl]amine (183006-17-9)

Conditions	Yield
With bis(chlorosulfonyl)amine In benzene for 2h; Heating;	96%

2,3-dichloro-pyridine (2402-77-9) + 2,2,3,3-tetrafluoropropanol (76-37-9) → 3-chloro-2-(2,2,3,3-tetrafluoropropyl)pyridine (1355067-32-1)

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluoropropanol With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h; Stage #2: 2,3-dichloro-pyridine In tetrahydrofuran; mineral oil for 16h; Reflux;	96%
Stage #1: 2,2,3,3-tetrafluoropropanol With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h; Stage #2: 2,3-dichloro-pyridine In tetrahydrofuran; mineral oil for 16h; Reflux;	96%

Nonanoyl chloride (764-85-2) + 2,2,3,3-tetrafluoropropanol (76-37-9) + carbon monoxide (201230-82-2) → C16H22F8O4

Conditions	Yield
Stage #1: Nonanoyl chloride; carbon monoxide With 2AlBr3*CBr4 at -20℃; under 735.576 Torr; for 1.45h; Stage #2: 2,2,3,3-tetrafluoropropanol at -20℃; under 735.576 Torr; regioselective reaction;	96%

2,2,3,3-tetrafluoropropanol (76-37-9) + Dichlorophenylphosphine (644-97-3) → di(1,1,3-trihydrotetrafluoropropyl)phenyl phosphonite (87651-42-1)

Conditions	Yield
at 20 - 25℃;	95%
In pyridine

2,2,3,3-tetrafluoropropanol (76-37-9) + 2-bromo-2,2-bis(2,2,3,3-tetrafluorpropoxy)-4,5-benzo-1,3,2-dioxaphospholane (127054-68-6) → 2-(2,2,3,3-tetrafluoropropoxy)-2-oxobenzo-1,3,2λ5-dioxaphosphole (127054-63-1)

Conditions	Yield
With triethylamine In dichloromethane at -40℃; for 0.5h;	94%

bromochlorobenzene (106-39-8) + 2,2,3,3-tetrafluoropropanol (76-37-9) → 1-chloro-4-(2,2,3,3-tetrafluoropropoxy)benzene

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluoropropanol With sodium In 1,4-dioxane Stage #2: bromochlorobenzene With N,N-dimethyl-formamide; copper(I) bromide In 1,4-dioxane at 110℃; for 6h; Sealed tube;	94%

2,2,3,3-tetrafluoropropanol (76-37-9) → bis(1,1,3-trihydroperfluoropropyl) sulfite (649-76-3)

Conditions	Yield
With HCF2CF2OCF2CF2SO2N=S=O for 1h; -20 deg C up to 25 deg C;	93%
With thionyl chloride; iron(III) chloride at 60℃; for 4h;	80%
With pyridine; thionyl chloride In diethyl ether at -20℃;

Upstream product

• 67-56-1 methanol 
• 116-14-3 polytetrafluoroethylene 
• 302-17-0 chloral hydrate 
• 358-33-8 bis(1,1,3-trihydroperfluoropropyl) hydrogen phosphate 
• 71879-02-2 pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane 
• 108-98-5 thiophenol 
• 106-53-6 para-bromobenzenethiol 
• 85878-21-3 C₁₂H₁₂F₁₆O₄Te 
• 65611-25-8 phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester 
• 121-44-8 triethylamine 
• 106-45-6 para-thiocresol 
• 106-54-7 p-Chlorothiophenol 
• 2241-68-1 tris(2,2,3,3-tetrafluoropropyl)phosphite 
• 87651-42-1 di(1,1,3-trihydrotetrafluoropropyl)phenyl phosphonite 

Downstream Products

• 756-04-7 2,2,3,3-tetrafluoropropionaldehyde 
• 1683-81-4 1,1,2,2-tetrafluoro-3-trifluoromethoxypropane 
• 16627-68-2 1,1,2,2-tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)propane 
• 65064-83-7 3-(2-Chloro-1,1,2-trifluoro-ethoxy)-1,1,2,2-tetrafluoro-propane 
• 6401-02-1 2,2,3,3-tetrafluoropropyl trifluoromethanesulfonate 
• 6146-01-6 Nonafluor-1-<2'.2'.3'.3'-tetrafluor-propoxy>-cyclohexen 
• 6156-67-8 Nonafluor-3-(2',2',3',3'-tetrafluor-propoxy)-cyclohexen 
• 65633-31-0 2-[4-(2,4-Dichloro-phenoxy)-phenoxy]-propionic acid 2,2,3,3-tetrafluoro-propyl ester 
• 65633-33-2 2-[4-(4-Chloro-phenoxy)-phenoxy]-propionic acid 2,2,3,3-tetrafluoro-propyl ester 
• 359-35-3 1,1,2,2-tetrafluoroethane 
• 1422-47-5 2,2,3,3-tetrafluoropropyl 2',2',3',3'-tetrafluoropropionate 
• 756-09-2 2,2,3,3-tetrafluoropropanoic acid 
• 58943-98-9 hexakis(1H,1H,3H-tetrafluoropropoxy)phosphazine 
• 59724-26-4 2,4-dichloro-2,4,6,6-tetrakis-(2,2,3,3-tetrafluoro-propoxy)-2λ⁵,4λ⁵,6λ⁵-cyclotriphosphazene 

Relevant academic research and scientific papers

Thermal desulfurization of (Alkoxymethyl)thiiranes

Reaction of (alkoxymethyl)oxiranes with thiourea in methanol has afforded the corresponding thiiranes, and catalyst-free thermal desulfurization of the products has been studied. The major products of desulfurization are alcohols and alkenes, both in the cases of (polyfluoroalkyloxymethyl)thiiranes and their non-fluorinated analogs. Longer alkyl chain in thiiranes favors formation of alcohols over alkenes formation in the course of desulfurization.

PROCESS FOR PRODUCING A-FLUOROALDEHYDES

A production process of an α-fluoroaldehyde according to the present invention includes reaction of an α-fluoroester with hydrogen gas (H2) in the presence of a ruthenium complex. It is possible in the present invention to allow relatively easy industrial production of the α-fluoroaldehyde and to directly obtain, as stable synthetic equivalents of the α-fluoroaldehyde, not only a hydrate (as obtained by conventional techniques) but also a hemiacetal that is easy to purify and is of high value in synthetic applications. The present invention provides solutions to all problems in the conventional techniques and establishes the significantly useful process for production of the α-fluoroaldehyde.

Polyfluoroalloxy phosphonic and phosphinic acid derivatives: I. 1-Hydroxy-2,2,2-trichloroethylphosphinates

Polyfluoroalkyl esters of 1-hydroxy-2,2,2-trichloroethylphosphonic and aryl(alkyl-)phosphinic acids exhibited antienzyme activity towards esterases of animal and microbial origin. A good correlation is observed between high antiesterase activity of the target compounds and their physicochemical parameters, characterizing their structure.

Polyfluoroalkoxy phosphonic and phosphinic acid derivatives: II. Reversible esterase inhibitors

Polyfluoroalkyl esters of phosphoric, alkylphosphonic and 1-hydroxypolyfluoroalkylphosphonic acids exhibited significant antiesterase activity against various esterases of animal and microbial origin. Moreover, with some compounds reversible inhibition of enzymes was observed due to the specific influence of hydrophobic fragments of the target products.

Transformation of perfluorinated benzocycloalkenes and alkylbenzenes to their carbonyl derivatives under the action of CF3COOH/SbF5

Perfluorinated benzocycloalkenes (benzocyclobutene, indan, tetralin), alkylbenzocycloalkenes and alkylbenzenes react with CF3COOH/SbF5 at 20-50 °C giving the corresponding carbonyl derivatives.

Spectrokinetic study of the reaction system of 2NO2?N 2O4 with some fluorinated derivatives of ethanol and propanols between 293-358 K in the gas phase

The gas phase kinetics of the reversible reactions between nitrogen tetroxide and some fluorinated alcohols in the reaction system 2NO 2?N2O4 (1, 2) N2O4 + ROH?RONO+ + HNO3 (3, 4) have been studied by UV-Vis spectrophotometry to follow the NO2 decay. The products - RONO (R = CH2FCH2, CHF2CH2, CF 3CH2, CHF2CF2CH2, CF 3CF2CH2, CF3CHCF3) - were identified by their UV spectra and the values of the maxima UV absorption cross sections were determined in the range 320-400 nm. The rate constants for the forward reaction are 10-19k3av/cm 3molec-1s-1 9.7±1.5; 2.5±0.4; 1.8±0.3; 23±3.5, 2.3±0.3, 0.2±0.03 and for the reverse reaction 10-19k4av/cm 3molec-1s-1 4.6±0.7; 5.5±0.8; 4.9±0.7; 9.1±1.4; 7.7±1.2; 23±3.5 at 298 K for the reaction with 2-fluoroethanol, 2,2-difluoroethanol, 2,2,2-trifluoroethanol, 2,2,3,3-tetrafluoro-1-propanol, 2,2,3,3,3-pentafluoro-1-propanol and 1,1,1,3,3,3-hexafluoro-2-propanol, respectively, were derived by the computer simulation of monitored NO2 decay profiles. The temperature dependence of the bimolecular rate constants k3 and k4 were studied in the temperature range 293-358 K and the activation energy for the forward E3 and for the reverse E4 reaction were derived. From the observed temperature dependence of the equilibrium constants K3,4, expressed in terms of the van't Hoff equation, the thermochemical parameters for all reactions studied were estimated.

Process for producing a fluoroalkanol

A process for producing a fluoroalkanol of high purity containing little evaporation residue, which can be industrially easily carried out with high selectivity, is provided. In the process, a radial initiator and CF2=CFR3 (formula 3) are continuously added to CHR1R2—OH (Formula 2) to react them to form H—(CFR3CF2)n—CR1R2—OH (formula 1). In the formulae, n is an integer of from 1 to 4, each of R1 and R2 is a hydrogen atom or a C1-3 alkyl group, and R3 is a fluorine atom or a C1-4 perfluoroalkyl group.

PROCESS FOR PRODUCING FLUOROALKANOL

A process for producing a fluoroalkanol of high purity containing little evaporation residue, which can be industrially easily carried out with high selectivity, is provided. In the process, a radial initiator and CF2=CFR3 (formula 3) are continuously added to CHR1R2-OH (Formula 2) to react them to form H-(CFR3CF2)n-CR1R2-OH (formula 1). In the formulae, n is an integer of from 1 to 4, each of R1 and R2 is a hydrogen atom or a C1-3 alkyl group, and R3 is a fluorine atom or a C1-4 perfluoroalkyl group.

PHOTOCHEMICAL SYNTHESIS OF FLUOROALKANOLS BASED ON TETRAFLUOROETHYLENE

The conditions of the photochemical synthesis of fluoroalkanols H(C2F4)nC(OH)R1R2 (n = 1, 2) by the reaction of tetrafluoroethylene with alcohols in the presence of photoinitiators and sensitisers are described.The reaction is initiated by UV radiation and is performed under atmospheric pressure.The yields of alkanols were 0.1-0.39 mol using 250 W UV lamp after 6-8 hours and 73-82 percent relatively to the converted tetrafluoroethylene.