6401-46-3Relevant academic research and scientific papers
PH-Dependent peptide bond formation by the selective coupling of α-amino acids in water
Wu, Long-Fei,Liu, Ziwei,Sutherland, John D.
supporting information, p. 73 - 76 (2021/01/13)
A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the amide bond. This journal is
Peptide ligation by chemoselective aminonitrile coupling in water
Canavelli, Pierre,Islam, Saidul,Powner, Matthew W.
, p. 546 - 549 (2019/07/31)
Amide bond formation is one of the most important reactions in both chemistry and biology1–4, but there is currently no chemical method of achieving α-peptide ligation in water that tolerates all of the 20 proteinogenic amino acids at the pepti
