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CBZ-Leu-Phe-OC(CH3)3, also known as Carbobenzyloxy-Leucine-Phenylalanine-Orthoformate, is a synthetic peptide derivative that consists of three amino acids: Leucine, Phenylalanine, and a protecting group, Carbobenzyloxy (CBZ). The orthoformate (OC(CH3)3) group is attached to the peptide, which serves as a temporary protecting group for the peptide's carboxyl group during synthesis. CBZ-Leu-Phe-OC(CH3)3 is commonly used in peptide synthesis as a building block, where the CBZ group protects the amino group of the peptide, and the orthoformate group protects the carboxyl group, allowing for controlled peptide chain elongation. The protecting groups are later removed to yield the desired peptide sequence.

6401-57-6

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6401-57-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6401-57-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,0 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6401-57:
(6*6)+(5*4)+(4*0)+(3*1)+(2*5)+(1*7)=76
76 % 10 = 6
So 6401-57-6 is a valid CAS Registry Number.

6401-57-6Relevant academic research and scientific papers

STUDIES ON AMINO ACIDS AND PEPTIDES X. HPLC-MEDIATED TEST OF 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE 2,4-DISULFIDE (LAWESSONS'S REAGENT) AS A RACEMIZATIONFREE COUPLING REAGENT IN PEPTIDE SYNTHESIS

Thorsen, M.,Andersen, T. P.,Pedersen, U.,Yde, B.,Lawesson, S.-O.,Hansen. H. F.

, p. 5633 - 5636 (2007/10/02)

The easily available 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (Lawesson's Reagent), 1, has been tested as a coupling reagent for racemization in peptide synthesis.The assay procedure is separation of stereomeric products by HPLC.Z-S-Pro-S-Val-S-Pro-OtBu and Z-S-Leu-S-Phe-S-Val-OtBu have been used as test peptides in 2+1 segment couplings, and only a small amount of epimerization (0.5 and 0.1percent, respectively) has been observed.

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