64022-27-1

Usage

Uses

Used in Pharmaceutical Industry:
MK 212 Hydrochloride is used as an anti-stress treatment for its ability to selectively activate the 5-HT2C serotonin receptor. This activation is believed to help alleviate stress and anxiety by modulating the serotonin levels in the brain, leading to a calming effect on the central nervous system.
Used in Research and Development:
MK 212 Hydrochloride is used as a research compound for studying the role of the 5-HT2C receptor in various physiological and pathological processes. It can be employed in preclinical studies to investigate the potential therapeutic effects of 5-HT2C agonism in conditions such as depression, anxiety, and other stress-related disorders.
Used in Antipsychotic Drug Development:
MK 212 Hydrochloride is used as a potential antipsychotic agent due to its selective agonist activity at the 5-HT2C receptor. It is being investigated for its ability to alleviate symptoms of psychotic disorders, such as schizophrenia, by modulating the serotonin signaling pathways in the brain.

Biological Activity

5-HT 2C serotonin receptor agonist.

Upstream product

• 110-85-0 piperazine 
• 4774-14-5 2,6-dichloropyrazine 
• 426829-52-9 tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate 

Downstream Products

• 1006699-36-0 (E)-3-[3-(3,4,5,6-Tetrahydro-2H-[1,2']bipyrazinyl-6'-yl)phenyl]acrylic acid 

Relevant academic research and scientific papers

Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors

Pim kinases are promising therapeutic targets for the treatment of hematological cancers. A potent Pim kinase inhibitor 7f, derived from meridianin C, was further optimized by the replacement of 2-aminopyrimidine with substituted benzene. The optimization of the C-3 and C-5 positions of indole yielded compound 43 with improved cellular potency and high selectivity against a panel of 14 different kinases.

NOVEL NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

A compound represented by general formula [1] wherein X represents N or the like, Y represents CH or the like; RA represents a cycloalkyl group which may be substituted or the like, R1 represents an alkyl group or the like, R2 represents an alkyl group which may be substituted or the like, R3 represents a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof has an inhibitory activity on aldosterone synthetase, and is useful as a prophylactic and/or therapeutic agent for various diseases or symptoms associated with aldosterone.

Hit to lead account of the discovery of a new class of inhibitors of pim kinases and crystallographic studies revealing an unusual kinase binding mode

A series of inhibitors of Pim-2 kinase identified by high-throughput screening is described. Details of the hit validation and lead generation process and structure-activity relationship (SAR) studies are presented. Disclosure of an unconventional binding mode for 1, as revealed by X-ray crystallography using the highly homologous Pim-1 protein, is also presented, and observed binding features are shown to correlate with the Pim-2 SAR. While highly selective within the kinase family, the series shows similar potency for both Pim-1 and Pim-2, which was expected on the basis of homology, but unusual in light of reports in the literature documenting a bias for Pim-1. A rationale for these observations based on Pim-1 and Pim-2 KM(ATP) values is suggested. Some interesting cross reactivity with casein kinase-2 was also identified, and structural features which may contribute to the association are discussed.

Parallel synthesis of N-arylpiperazines using polymer-assisted reactions

A series of N-arylpiperazines were prepared in a parallel fashion using palladium-catalyzed cross-coupling, or nucleophilic aromatic displacement chemistries, and polymer-assisted sequestration and purification techniques as key steps.

Piperazinylpyrazines with central serotoninmimetic activity.

A series of 2-(1-piperazinyl)pyrazines was synthesized and evaluated for central serotonin-like activity. The most interesting member of the series, 6-chloro-2(1-piperazinyl)pyrazine (3a), had pharmacological properties characteristic of potent central serotoninmimetic activity and only weak peripheral serotoninmimetic action. Structural similarities between 3a and serotonin are discussed.

6-Chloro-2-(1-piperazinyl)pyrazine

The compound 6-chloro-2-(1'-piperazinyl)pyrazine, its N-oxides and acid-addition salts are disclosed having pharmacological activity as anorexic agents.