64026-55-7Relevant academic research and scientific papers
Silyl Route of Lactam Alkylation in Syntheses of Lactamodipeptide Amides
Shipov,Kramarova,Kalashnikova,Besova,Baukov
, p. 1736 - 1741 (2007/10/03)
A general route to lactamodipeptide amides is proposed, based on reaction of N-trimethylsilyl-lactams with ethoxycarbonylmethyl chloroacetate, followed by reaction of the resulting ethoxycarbonylmethyl esters of lactamoacetic acids with esters of amino ac
POTENTIAL NOOTROPIC AGENTS: SYNTHESIS OF SOME (2-OXO-1-PYRROLIDINYL)ACETAMIDES AND SOME RELATED COMPOUNDS
Valenta, Vladimir,Holubek, Jiri,Svatek, Emil,Valchar, Martin,Krejci, Ivan,Protiva, Miroslav
, p. 2756 - 2764 (2007/10/02)
Ethyl (2-oxo-1-pyrrolidinyl)acetate was transformed by ester exchange to the 2-dimethylaminoethyl ester VI which was converted to the choline iodide ester VII.The mixed anhydride of (2-oxo-1-pyrrolidinyl)acetic acid and monoethyl carbonate was reacted with ethyl aminoacetate to give the ester VIII which was transformed on the one hand to the amide IX, and to the 2-dimethylaminoethyl ester X on the other.Reaction of the latter with methyl iodide afforded a further choline iodide ester XI.Reactions of (2-oxo-1-pyrrolidinyl)acetyl chloride with 4-chloroaniline and 3-aminopyridine gave the amides XII and XIV.The anilide XIII was obtained from 2-(2-oxo-1-pyrrolidinyl)butyric acid and 4-chloroaniline by means of dicyclohexylcarbodiimide.The benzo analogue (XV) of piracetam (I) was synthesized from oxindole via the ester XVI.The anilide XII (VUFB-16 536) was found to potentiate significantly the anticonvulsant effect of diazepam in mice, to prolong the survival time of mice under conditions of nitrogen anoxia, and to prolong significantly the duration of the "gasping reflex" in mice.
N-substituted lactams
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, (2008/06/13)
New physiologically active N-substituted lactams having the formula STR1 wherein R1, R2, R3, R4, R5, R6 and R7, represent independently a hydrogen atom, an alkyl radical containi
