53934-76-2

Usage

Uses

Used in Pharmaceutical Industry:
(2-OXOPYRROLIDIN-1-YL)ACETIC ACID is used as a reagent for the preparation of pyrazolopyridines, which are known as PDE4B inhibitors. These inhibitors play a significant role in the treatment of various inflammatory and autoimmune diseases by modulating the activity of phosphodiesterase 4B (PDE4B), an enzyme involved in the regulation of inflammatory processes. (2-OXOPYRROLIDIN-1-YL)ACETIC ACID's ability to facilitate the synthesis of these inhibitors makes it an essential component in the development of novel therapeutic agents for a wide range of medical conditions.

InChI:InChI=1/C6H9NO3/c8-5-2-1-3-7(5)4-6(9)10/h1-4H2,(H,9,10)

Upstream product

• 616-45-5 2-pyrrolidinon 
• 50-00-0 formaldehyd 
• 201230-82-2 carbon monoxide 
• 79-08-3 bromoacetic acid 
• 59776-89-5 2-(2-oxopyrrolidin-1-yl)acetylhydrazide 
• 59776-90-8 Dupracetam 
• 59776-88-4 methyl-2-oxopyrrolidine-1-acetate 
• 543-24-8 N-acetylglycine 
• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 497250-66-5 2-(oxo-pyrrolidin-1-yl)-acetic acid tert-butyl ester 
• 143023-95-4 benzyl 2-(1'-aza-2'-oxocyclopentyl)ethanoate 
• 142274-08-6 (4-ethoxy-1,5-dihydro-2-oxo-2H-pyrrol-1-yl)acetic acid 
• 105-36-2 ethyl bromoacetate 
• 142274-11-1 2,4-dioxopyrrolidin-1-yl-acetic acid 

Downstream Products

• 1075715-78-4 1-{2-[8-Fluoro-1-oxo-3-((S)-1-phenyl-propylamino)-1H-isochromen-4-yl]-2-oxo-ethyl}-pyrrolidin-2-one 
• 1190615-41-8 tert-butyl (2R,5S)-2-[(R)-hydroxy(pyridin-3-yl)methyl]-5-(4-{[(2-oxopyrrolidin-1-yl)acetyl]amino}benzyl)pyrrolidine-1-carboxylate trifluoroacetate 
• 64026-55-7 ((2-oxo-1-pyrrolidinyl)acetamido)cetamide 
• 73193-59-6 diethyl 3-oxopiperidine-1,4-dicarboxylate 
• 774605-29-7 3-(2,6-dichloro-phenyl)-5-(2-oxo-pyrrolidin-1-ylmethyl)-isoxazole-4-carboxylic acid ethyl ester 
• 774605-53-7 3-(2,6-dichloro-phenyl)-5-(2-oxo-pyrrolidin-1-ylmethyl)-isoxazole-4-carboxylic acid 
• 62563-06-8 dimethyl 2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate 
• 6908-67-4 (E)-1-(2-phenylethenyl)-2-pyrrolidinone 

Relevant academic research and scientific papers

Synthesis of N-Lauroyl Sarcosine by Amidocarbonylation: Comparing Homogeneous and Heterogeneous Palladium Catalysts

An improved system for the synthesis of N-acyl amino acids via Pd-catalyzed amidocarbonylation is reported. Utilizing inexpensive Pd black gives the industrially important surfactant N-lauroyl sarcosine in excellent yields (95%) on a multi-gram scale. Advantages of the new system include reusability, decreased process temperature, and, importantly, drastically decreased co-catalyst loading.

ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS

The invention relates to isoquinolinone derivatives useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds.

ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS

The invention relates to compounds useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds.

ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS

Isoquinolone derivatives of the general formula (I) are NK3 antagonists.

ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS

Isoquinolone derivatives of the general formula are provided. The compounds are NK3 antagonists and useful for the treatment of e.g. psychosis and schizophrenia.

Facile synthesis of gold icosahedra in an aqueous solution by reacting HAuCl4 with N-vinyl pyrrolidone

Herein we describe a protocol that generates Au icosahedra in high yields by simply mixing aqueous solutions of HAuCl4 and N-vinyl pyrrolidone. Our mechanistic study reveals that water plays an important role in this synthesis: as a nucleophile

CHEMOKINE RECEPTOR BINDING COMPOUNDS

The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. Thesd compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

Ramoplanin derivatives possessing antibacterial activity

Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

NK1 and NK3 antagonists

The invention is to a compound exhibiting neurokinin inhibitory properties, a pharmaceutical composition comprising same and a method of treatment for neurokinin-mediated conditions.