640285-93-4Relevant academic research and scientific papers
One-Pot Synthesis of Homoallylic Ketones from the Addition of Vinyl Grignard Reagent to Carboxylic Esters
Hansford, Karl A.,Dettwiler, James E.,Lubell, William D.
, p. 4887 - 4890 (2003)
(Equation Presented) Fifteen homoallylic ketones have been synthesized in 26-77% yields on treatment of aromatic, aliphatic, and α-amino methyl carboxylates with excess vinylmagnesium bromide and catalytic amounts of a copper salt in THF. α-Amino homoallylic ketones derived from N-protected α-amino esters possessing aliphatic and alcohol side chains were synthesized in ≥98% enantiomeric purity.
