64035-64-9

Usage

InChI:InChI=1/C5H11F3O3SSi/c1-13(2,3)4-11-12(9,10)5(6,7)8/h4H2,1-3H3

Upstream product

• 3219-63-4 (trimethylsilyl)methanol 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 186581-53-3 diazomethane 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 

Downstream Products

• 118-12-7 1,3,3-Trimethyl-2-methyleneindoline 
• 114676-05-0 dimethyl 9,9a-dihydro-9,9,9a-trimethyl-3H-pyrrolo<1,2a>indole-1,2-dicarboxylate 
• 114676-06-1 10b,11,17a,18-tetrahydro-11,11,18,18-tetramethyl-17a-phenyl-6H,17H,diindolo<1,2-a:1,2-d>benzo<1,4>diazocine 
• 114676-07-2 dimethyl rel-(1R,2S,9aR)-2,3,9,9a-tetrahydro-9,9-dimethyl-9a-phenyl-1H-pyrrolo<1,2-a>indole-1,2-dicarboxylate 
• 114718-05-7 dimethyl rel-(1S,2R,9aR)-2,3,9,9a-tetrahydro-9,9-dimethyl-9a-phenyl-1H-pyrrolo<1,2-a>indole-1,2-dicarboxylate 
• 114676-08-3 dimethyl 9,9a-dihydro-9,9-dimethyl-9a-phenyl-1H-pyrrolo<1,2a>indole-1,2-dicarboxylate 
• 114718-06-8 rel-(1S,2S,9aR)-2,3,9,9a-tetrahydro-9,9-dimethyl-9a-phenyl-1H-pyrrolo<1,2-a>indole-1,2-dicarboxylate 
• 113638-05-4 4,4,5,5-Tetra-p-tolyl-[1,3]dithiolane 
• 104156-53-8 Trifluoro-methanesulfonate[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-methyl-trimethylsilanylmethyl-ammonium; 
• 113638-06-5 4,4,5,5-Tetrakis-(4-chloro-phenyl)-[1,3]dithiolane 
• 40595-34-4 (E)-trimethyl(3-phenylallyl)silane 
• 96245-48-6 3-<(phenylthio)methyl>-2-methylenecyclopentan-1-one 

Relevant academic research and scientific papers

RAPAMYCIN ANALOGS AS ANTI-CANCER AGENTS

Analogs and derivatives of rapamycin are provided, wherein the analogs and derivatives can bind to FK-506 binding protein (FKBP), or inhibit the mTOR function of an FKBP, or both. The analogs and derivatives are rapamycin include the rapamycin skeleton su

Preparation of (Trimethylsilyl)methyl Halides and Trifluoromethanesulfonate by Methylene Insertion Using Diazomethane

(Trimethylsilyl)methyl halides (1,3) and trifluoromethanesulfonate (triflate) (2) were prepared by inserting a methylene group into the silicon-heteroatom bond of trimethylsilyl halides and triflate using diazomethane.

Synthesis and Antineoplastic Activity of Bisoxy>methyl>-Substituted 3-Pyrrolines as Prodrugs of Tumor Inhibitory Pyrrole Bis(carbamates)

A series of bispyrrolines 2-4 were synthesized from either the appropriate α-silylated iminium salt, or an aziridine, or a 2H-azirine in a sequence involving 1,3-dipolar cycloaddition reactions.The antineoplastic activities of the pyrrolines were compared to the corresponding pyrroles.The C-2 gem-dimethyl-substituted pyrroline, 4, which cannot be converted to the pyrrole in vivo, was inactive.The activity of the 2-phenyl-substituted pyrrolines 3 was markedly dependent on the nature of the phenyl substituent, although the correspondingphenylpyrroles all showed comparable activity.The differences in the activities of the pyrrolines 3 may be due to the rate of metabolic conversion of the pyrroline to the pyrrole.Electron-withdrawing substituents on the phenyl ring appear to retard this process.

Dienophilic Properties of Phenyl Vinyl Sulfone and trans-1-(Phenylsulfonyl)-2-(trimethylsilyl)ethylene. Their Utilization as Synthons for Ethylene, 1-Alkenes, Acetylene, and Monosubstituted Alkynes in the Construction of Functionalized Six-Membered Rings via ? Cycloaddition Meth.

Useful procedures for effecting the indirect capture of ethylene, acetylene, 1-alkenes, and monosubstituted alkynes in Diels-Alder cycloadditions have been developed.In the first sequence, phenyl vinyl sulfone is shown to enter into ? reactions as a moderately reactive dienophile and to do so with very good regioselectivity.The resulting adducts can be directly desulfonated or alkylated prior to such reduction.A wide range of functional groups can be appended in this fashion at a specific locus within the newly formed six-membered ring.When the analogous chemistry is applied to trans-1-(phenylsulfonyl)-2-(trimethylsilyl)ethylene (2), adducts result which undergo ready fluoride ion induced elimination with efficient introduction of a double bond.The use of 2 and its d2 derivative is highlighted by the synthesis of several functionalized dibenzobarrelenes.