64037-30-5

Usage

Uses

Used in Pharmaceutical Industry:
6-Amino-5-chlorobenzoxazol-2(3H)-one is used as a building block for the synthesis of various pharmaceuticals and organic compounds due to its unique structure and potential biological activities.
Used in Medicinal Chemistry:
6-Amino-5-chlorobenzoxazol-2(3H)-one is used as a starting material for the development of new drugs in medicinal chemistry, given its antimicrobial and antitumor activities, which may lead to the creation of novel therapeutic agents.
Used in Antimicrobial Applications:
6-Amino-5-chlorobenzoxazol-2(3H)-one is used as an antimicrobial agent for its potential to combat various microorganisms, which can be beneficial in the development of new antibiotics and antifungal agents.
Used in Antitumor Applications:
6-Amino-5-chlorobenzoxazol-2(3H)-one is used as an antitumor agent for its potential to inhibit the growth of cancer cells, making it a candidate for further research and development in oncology.
Used in Biological Activity Research:
6-Amino-5-chlorobenzoxazol-2(3H)-one is used in biological activity research to explore its potential implications in medicinal chemistry, which may contribute to the advancement of drug discovery and development.

InChI:InChI=1/C7H5ClN2O2/c8-3-1-5-6(2-4(3)9)12-7(11)10-5/h1-2H,9H2,(H,10,11)

Upstream product

• 27087-06-5 5-chloro-6-nitrobenzo[d]oxazol-2(3H)-one 
• 6358-07-2 2-amino-4-chloro-5-nitrophenol 

Relevant academic research and scientific papers

Design, Synthesis and Herbicidal Activities of Tetrahydroisoindoline-1,3-dione Derivatives Containing Alkoxycarbonyl Substituted 2-Benzoxazolinone

Several different alkoxycarbonyl-substituted 2-benzoxazolinone moieties have been incorporated into a tetrahydroisoindoline-1,3-dione scaffold to provide 25 compounds (1a-1u and 2a-2d). The structures of these compounds were confirmed by 1H and 13C NMR, HRMS and X-ray single-crystal diffraction. Some of these compounds (1g, 1h, 1j, 1k) exhibited excellent herbicidal activities against Abutilon theophrasti, Amaranthus retroflexus and Echinochloa crus-galli at a rate of 375 g AI·ha-1. Among them, compounds 1h and 1j displayed the best post-emergence herbicidal effect against Abutilon theophrasti with ED50 values of 1.8 and 5.3 g AI·ha-1, respectively, which are superior to that of the commercial acifluorfen (44.3 g AI·ha-1). Field trials demonstrated that compound 1h exhibited similar herbicidal activity to a high concentration atrazine, and found to be safer for maize than atrazine. The results of this study therefore show that compound 1h could potentially be used as a post-emergence herbicide for maize fields. Two series of tetrahydroisoindoline-1,3-diones containing an alkoxycarbonyl substituted 2-benzoxazolinone moiety were designed and synthesized. Compound 1h displayed excellent herbicidal effect against Abutilon theophrasti with ED50 values of 1.8 g AI·ha-1, and compound 1h could potentially be used as a new post-emergence herbicide for maize fields.

Iminoisoindoline pigments and processes for the preparation thereof

Iminoisoindolinone pigments of the formula SPC1 Wherein X represents halogen atoms, Y represents a halogen atom, an alkoxy, cycloalkoxy, aralkoxy, aryloxy, alkylthio or arylthio group, R represents an aromatic radical containing a cyclic bound -CONH group, and Q represents an O-atom or the group =N--R and are useful for coloring plastics and lacquers in yellow shades having excellent fastness properties.