64057-62-1Relevant academic research and scientific papers
A comparison of steroidal and non-steroidal inhibitors of human steroid 5α-reductase: New tricyclic aryl acid inhibitors of the type-1 isozyme
Abell, Andrew D.,Brandt, Martin,Levy, Mark A.,Holt, Dennis A.
, p. 481 - 484 (1996)
A series of 9,10-dihydrophenanthrene-2-carboxylic acids has been prepared and evaluated in vitro as inhibitors of human recombinant steroid 5α-reductase. 7-Bromo-9,10-dihydrophenanthrene-2-carboxylic acid, 8c, is a potent and selective non-steroidal inhibitor of human type-1 steroid 5α-reductase (K(i,app) 26 nM). The inhibitory activity relationships of steroidal and non-steroidal inhibitors, with 4-aza, 16-aza, diene acid, aryl acid and nitro-alkenes functionalities, are considered.
SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C
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Page/Page column 212, (2014/09/29)
This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)- amides of formula (1) and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C
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Paragraph 0548; 0549, (2014/09/29)
This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid(benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
Diene-yne cyclisation reactions of 1-ethynyl-2-vinyl-3,4- dihydronaphthalenes and 1-ethynyl-2-vinylnaphthalenes
Watanabe, Masataka,Shiine, Kodai,Ldeta, Keiko,Matsumoto, Taisuke,Thiemann, Thies
experimental part, p. 669 - 678 (2009/09/06)
The reaction of 1-ethynyl-2-vinyl-3,4-dihydronaphthalenes and 1-ethynyl-2-vinylnaphthalenes over RuCI2(p-cymene) PPh3 leads to 9,10-dihydrophenanthrenes and phenanthrenes in those cases where the ethynyl group in the substrates carries a terminal proton. When 1-phenylethynyl-2-vinyl-3,4-dihydronaphthalenes or 1-phenylethynyl-2- vinylnaphthalenes are reacted over Pt(PPh3)4, 1-methylene-1H-benz[e]-4,5-dihydroindenes and 1-methylene-1H-benz[e]indenes are formed.
Dibenzanthracene via Photo-cyclodehydrogenation of 9,10-Dihydro-2-styrylphenanthrene
Diederich, Francois,Schneider, Karin,Staab, Heinz A.
, p. 1255 - 1258 (2007/10/02)
Waehrend aus 2-Styrylphenanthren (1) durch Photocyclodehydrierung Benzochrysen (2) entsteht, laesst sich unter Ausnutzung der "ΣF*-Regel" aus 9,10-Dihydro-2-styrylphenanthren (4) durch Photocyclodehydrierung zu 6 und anschliessende Dehydrierung Dibenzanthracen (3) erhalten.
PROPERTIES OF THE LIQUID CRYSTALS FORMED BY CERTAIN 4-ALKOXY-N-(9,10-DIHYDRO-2-PHENANTHRYLMETHYLENE)ANILINES
Brown, John W.,Byron, David J.,Harwood, David J.,Smith, Neil M.,Wilson, Robert C.
, p. 271 - 274 (2007/10/02)
The liquid crystal transition temperatures of twelve 4-alkoxy-N-(9,10-dihydro-2-phenanthrylmethylene)anilines are reported and discussed.The liquid crystal behaviour of the homologous series is very similar to that of the analogous compounds in which the -CH=N- linkage is reversed.The form of the transition temperature plots indicates the existence of very low lateral relative to terminal cohesive forces in the mesophases of the azomethine derivatives of 9,10-dihydriphenanthrene.
