64065-24-3Relevant academic research and scientific papers
α-C-H Alkylation of Methyl Sulfides with Alkenes by a Scandium Catalyst
Luo, Yong,Ma, Yuanhong,Hou, Zhaomin
supporting information, p. 114 - 117 (2018/01/17)
The C - H addition of sulfides to alkenes is an atom-efficient route for the functionalization and modification of sulfide compounds through C - C bond formation, but this transformation is highly challenging. We report here the regioselective α-C(sp3) - H addition of a wide range of methyl sulfides to a variety of olefins and dienes by a half-sandwich scandium catalyst. This protocol provides a unique route for the synthesis of diverse sulfide derivatives through C - C bond formation at a sulfur-adjacent carbon atom in a 100% atom efficient fashion.
Controlled anion migrations with a mixed metal Li/K-TMP amide: General application to benzylic metalations
Fleming, Patricia,Oshea, Donal F.
supporting information; experimental part, p. 1698 - 1701 (2011/04/17)
A general method is described for benzylic metalation of o-, m-, and p-substituted toluenes using a mixed metal amide base generated from BuLi/KOtBu/TMP at -78 °C in THF. The excellent selectivity achieved can be rationalized by the ability of the mixed metal amide base to facilitate an anion migration from the kinetic (o-aryl) to the benzylic metalation site. Remarkably, this controlled anion migration is achievable with catalytic amounts of TMP at -78 °C.
