64067-98-7

Usage

Uses

Used in Pharmaceutical Industry:
(6-Chloro-iMidazo[1,2-b]pyridazin-2-yl)-acetic acid ethyl ester is used as a key intermediate in the synthesis of pharmaceuticals for the development of new drugs to treat various medical conditions. Its unique structure allows it to be a versatile component in the creation of biologically active compounds.
Used in Agrochemical Industry:
In the agrochemical field, (6-Chloro-iMidazo[1,2-b]pyridazin-2-yl)-acetic acid ethyl ester is utilized as a building block for the production of agrochemicals, contributing to the development of effective solutions for agricultural applications.
Used in Organic Synthesis:
(6-Chloro-iMidazo[1,2-b]pyridazin-2-yl)-acetic acid ethyl ester is employed as a valuable component in organic synthesis, enabling the creation of a wide range of chemical compounds for research and industrial purposes.
Used in Medicinal Chemistry Research:
(6-Chloro-iMidazo[1,2-b]pyridazin-2-yl)-acetic acid ethyl ester is also used in medicinal chemistry research as a starting material for the design and synthesis of potential drug candidates, owing to its distinctive chemical structure and functional groups.

Upstream product

• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 144-55-8 sodium hydrogencarbonate 
• 13176-46-0 4-bromoethyl acetoacetate 

Downstream Products

• 64068-07-1 (6-chloroimidazo[1,2-b]pyridazine-2-yl)acetic acid 

Relevant academic research and scientific papers

TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TNF

Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: -(CR3R3)2-5-, -(CR3R3)x-Y-(CR3R3)y-, -Y-(CR3R3)2-3-Y-, -CR3R3-Y-(CR3R3)2-Y-,-Y-(CR3R3)2-Y-CR3R3-; and Y, R1, R2, R3, R5, R6, R8, x, and y are define herein. Also disclosed ar

Condensed pyridazine derivatives, their production and use

A condensed pyridazine derivative which is useful as a pharmaceutical composition for preventing or treating allergic skin diseases such as contact dermatitis, pruritus, dried dermatitis, acute urticaria and prurigo.

Condensed pyridazine derivatives, their production and use

The present invention provides a compound represented by the formula: wherein Ar1 and Ar2 are independently an aromatic group which may be substituted, and Ar1 and Ar2 may form a condensed cyclic group with an adjacent carbon atom; ring B is a nitrogen-containing heterocycle which may be substituted; X and Y are the same or different and are independently a bond, an oxygen atom, S(O)p (p is an integer of 0 ot 2), NR4 wherein R4 is a hydrogen atom or a lower alkyl group, or a bivalent linear lower hydrocarbon group which may contain 1 to 3 hetero atoms and the bivalent linear lower hydrocarbon group may be substituted; A is a nitrogen atom or CR7 wherein R7 is a hydrogen atom, a halogen atom, a hydrocarbon which may be substituted, an acyl group or a hydroxy group which may be substituted; R1, R2 and R3 are the same or different and are independently a hydrogen atom, a halogen atom, a hydrocarbon group which may be substituted, an acyl group or a hydroxy group which may be substituted; R8 is a hydrogen atom, a hydroxy group which may be substituted by a lower alkyl or a carboxyl group, or a salt thereof, which exhibits excellent anti-histaminic or eosinophil chemotaxis-inhibiting activities and is useful in treatment or prevention of asthma, allergic conjunctivitis, allergic rhinitis, chronic urticaria or atopic dermatitis.

Research on heterocyclic compounds. XXXIII-synthesis and analgesic activity of imidazo[1,2-b]pyridazine-2-acetic acid derivatives

A series of imidazo[1,2-b]pyridazine-2-acetic esters, acids and amides was synthesized and tested for antiinflammatory, analgesic and ulcerogenic activities. The ethyl esters were prepared by cyclocondensation of some 3-aminopyridazines with ethyl 4-chloroacetoacetate, followed by hydrolysis or amminolysis in order to obtain the corresponding acids and amides. The capacity of inhibiting the sarrageenan-induced edema in the rat paw and the writhes induced by acetic acid in mice were evaluated, as well as the ulcerogenic action in rats. The acid is derivatives showed significant analgesic activity which is comparable to that found in other series of imidazo[1,2-b]pyridazine analogs previously examined.