64072-89-5 Usage
Uses
Used in Pharmaceutical Industry:
9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID is used as a pharmaceutical agent for its potential therapeutic applications. Due to its chemical instability and short half-life, research is focused on developing methods to stabilize PGD2 and enhance its bioavailability for use in various medical treatments.
Used in Research and Development:
In the field of research and development, 9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID is used as a key compound in studying the metabolism and biological effects of prostaglandins. Understanding the pathways and interactions of PGD2 and its decomposition products, such as Δ12-PGD2 and Δ12-PGJ2, can provide valuable insights into the development of new drugs and therapies.
Used in Drug Metabolism Studies:
9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID is used as a subject in drug metabolism studies to investigate the addition of thiol nucleophiles, a common reaction for cyclopentenone prostaglandins. This research can contribute to the development of new drugs with improved stability and efficacy.
Used in Anticancer Applications:
Although not explicitly mentioned in the provided materials, due to the antimitotic and carcinogenic activities of Δ12-PGJ2, which is derived from PGD2, it is plausible that 9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,12E-DIEN-1-OIC ACID could be used as a starting point for the development of anticancer agents. Further research would be required to explore this potential application.
Check Digit Verification of cas no
The CAS Registry Mumber 64072-89-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,0,7 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 64072-89:
(7*6)+(6*4)+(5*0)+(4*7)+(3*2)+(2*8)+(1*9)=125
125 % 10 = 5
So 64072-89-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,13,15-16,18,21-22H,2-3,5-6,8-12,14H2,1H3,(H,24,25)/b7-4-,17-13+/t15-,16+,18-/m0/s1
64072-89-5Relevant academic research and scientific papers
Synthesis and Platelet Aggregation Inhibiting Activity of Prostaglandin D Analogues
Bundy, Gordon L.,Morton, D. R.,Peterson, D. C.,Nishizawa, E. E.,Miller, W. L.
, p. 790 - 799 (2007/10/02)
Several prostaglandin D (PGD) analogues have been synthesized, incorpotating the following variations: (a) varying degrees of side-chain unsaturation, (b) C-9 hydroxy removed or in the unnatural 9β configuration, (c) metabolically stabilized analogues (e.
9-Deoxy-PGF2 Analogs
-
, (2008/06/13)
Prostaglandin analogs with the following cyclopentane ring structure: STR1 are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for some of the same pharmacological purposes as the prostaglandins.
