64073-87-6Relevant academic research and scientific papers
Iodine (III)-mediated synthesis of some 2-aryl/ hetarylbenzoxazoles as antibacterial/antifungal agents
Kumar, Ravi,Nair, Reshmi R.,Dhiman, Saurabh Sudha,Sharma, Jitender,Prakash, Om
experimental part, p. 541 - 550 (2011/11/01)
Ten 2-aryl/hetarylbenzoxazoles (5a, 5b, and 6a-h) were synthesized via oxidative cyclization of Schiff bases (3a, 3b, and 4a-h) with 1.1 equivalent of iodobenzene diacetate (IBD) in methanol. All of these 2-aryl/hetarylbenzoxazoles (5a, 5b, and 6a-h) were tested in vitro for their antibacterial and antifungal activities against Bacillus subtilis, Bacillus stearothermophilus, Escherichia coli, and Pseudomonas putida. These compounds also were screened for their antifungal activity against Aspergillus flavus and Aspergillus niger. Biological activity of these compounds was compared with those of commercially available antibiotics, chloramphenicol and antifungal agent cycloheximide. Most of these compounds, 5a, 5b, 6a, 6b, 6d, 6e, 6g, 6h, were equipotent or more potent than these commercial drugs at concentration 100 μg/ml. Birkhaeuser Boston 2009.
Hypervalent iodine(III) mediated synthesis of 2-substituted benzoxazoles
Prakash, Om,Batra, Anita,Sharma, Vijay,Saini, Rajesh K.,Verma, Rajender S.
, p. 1031 - 1034 (2007/10/03)
2-Substituted benzoxazoles (6a-j, 7a-e, 7j-l) have been synthesized via the oxidative intramolecular cyclization of Schiff's bases (4a-j, 5a-e, 5j-l) using iodobenzene diacetate (IBD) as an oxidant in dry methanol. A one-pot procedure for the synthesis of 6a-j, 7a-e and 7j-l starting from o-aminophenol/p-chloro-o- aminophenol and aldehydes has also been developed.
