893-18-5

Upstream product

• 89-64-5 p-chloro-o-nitrophenol 
• 555-16-8 4-nitrobenzaldehdye 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 95-55-6 2-amino-phenol 
• 122-04-3 4-nitro-benzoyl chloride 
• 3743-17-7 N-(2-hydroxy-phenyl)-4-nitro-benzamide 
• 64073-87-6 4-chloro-2-(4-nitro-benzylidenamino)-phenol 

Relevant academic research and scientific papers

Iron(III) Chloride Mediated para-Selective C-H Functionalization: Access to C5-Chloro and C5,C7-Dichloro/Dianisyl Substituted 2-Arylbenzoxazoles

Iron(III) chloride mediated para-selective C?H chlorination and subsequent annulation of 2-amidophenol to synthesize C5- and C5, C7-chlorinated benzoxazoles was developed. Further, the oxidative cross-dehydrogenative coupling of amidophenol with anisole b

KMnO4/HOAc system promoted one-pot synthesis of benzoxazoles from o-aminophenols or oxidative cyclization of o-hydroxyarylidene anilines at room temperature

1,3-Benzoxazoles via oxidative cyclization of corresponding o-hydroxyarylidene anilines was synthesized in the presence of KMnO4/HOAc system. This system also was applied for the one-pot synthesis of 1,3-benzoxazoles from o-amino phenols and aldehydes. The both protocols were processed at room temperature under solvent-free conditions with good to excellent yields.

Iodine (III)-mediated synthesis of some 2-aryl/ hetarylbenzoxazoles as antibacterial/antifungal agents

Ten 2-aryl/hetarylbenzoxazoles (5a, 5b, and 6a-h) were synthesized via oxidative cyclization of Schiff bases (3a, 3b, and 4a-h) with 1.1 equivalent of iodobenzene diacetate (IBD) in methanol. All of these 2-aryl/hetarylbenzoxazoles (5a, 5b, and 6a-h) were tested in vitro for their antibacterial and antifungal activities against Bacillus subtilis, Bacillus stearothermophilus, Escherichia coli, and Pseudomonas putida. These compounds also were screened for their antifungal activity against Aspergillus flavus and Aspergillus niger. Biological activity of these compounds was compared with those of commercially available antibiotics, chloramphenicol and antifungal agent cycloheximide. Most of these compounds, 5a, 5b, 6a, 6b, 6d, 6e, 6g, 6h, were equipotent or more potent than these commercial drugs at concentration 100 μg/ml. Birkhaeuser Boston 2009.

Efficient aerobic oxidative synthesis of 2-substituted benzoxazoles, benzothiazoles, and benzimidazoles catalyzed by 4-Methoxy-TEMPO

(Chemical Equation Presented) Setting the TEMPO: The scheme shows the efficient aerobic synthesis of 2-substituted benzoxazoles, benzothiazoles, and benzimidazoles where 4-methoxy-2,2,6,6-tetramethyl-1-piperidinyloxy free radical (4-Methoxy-TEMPO) is used as the catalyst.

Hypervalent iodine(III) mediated synthesis of 2-substituted benzoxazoles

2-Substituted benzoxazoles (6a-j, 7a-e, 7j-l) have been synthesized via the oxidative intramolecular cyclization of Schiff's bases (4a-j, 5a-e, 5j-l) using iodobenzene diacetate (IBD) as an oxidant in dry methanol. A one-pot procedure for the synthesis of 6a-j, 7a-e and 7j-l starting from o-aminophenol/p-chloro-o- aminophenol and aldehydes has also been developed.