640769-65-9

Basic information

• Product Name: 3',4'-DIMETHOXYBIPHENYL-4-CARBALDEHYDE
• Synonyms: 3',4'-DIMETHOXYBIPHENYL-4-CARBALDEHYDE;4-(3,4-DIMETHOXYPHENYL)BENZALDEHYDE
• CAS NO: 640769-65-9
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.27
• Mol File: 640769-65-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 377.9°Cat760mmHg
• Flash Point: 173.8°C
• Appearance: /
• Density: 1.13g/cm³
• CAS DataBase Reference: 3',4'-DIMETHOXYBIPHENYL-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-DIMETHOXYBIPHENYL-4-CARBALDEHYDE(640769-65-9)
• EPA Substance Registry System: 3',4'-DIMETHOXYBIPHENYL-4-CARBALDEHYDE(640769-65-9)

Safety Data

• Hazardous Substances Data: 640769-65-9(Hazardous Substances Data)

Usage

General Description

3',4'-DIMETHOXYBIPHENYL-4-CARBALDEHYDE, also known as DMBC, is an organic compound that is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It belongs to the class of chemicals known as aldehydes, and it is characterized by its aromatic structure and the presence of two methoxy groups on the benzene ring. DMBC is often used as a starting material in various organic reactions and is known for its mild and selective reactivity. It is also commonly used as a reagent in the synthesis of complex organic molecules. Additionally, DMBC has been studied for its potential applications in the development of new materials and for its biological activities. Overall, 3',4'-DIMETHOXYBIPHENYL-4-CARBALDEHYDE is an important and versatile chemical with a wide range of applications in the pharmaceutical, agrochemical, and materials industries.

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 2859-78-1 4-Bromoveratrole 
• 87199-17-5 4-formylphenylboronic acid, 
• 760987-49-3 4-(3,4-dimethoxyphenyl)benzyl bromide 
• 1122-91-4 4-bromo-benzaldehyde 
• 760987-73-3 4-(3,4-dimethoxyphenyl)benzyl alcohol 

Relevant articles and documents

Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors

CYP121 of Mycobacterium tuberculosis (Mtb) is an essential target for the development of novel potent drugs against tuberculosis (TB). Besides known antifungal azoles, further compounds of the azole class were recently identified as CYP121 inhibitors with

Palladium-catalysed room-temperature Suzuki–Miyaura coupling in water extract of pomegranate ash, a bio-derived sustainable and renewable medium

An agro waste-derived, ‘water extract of pomegranate ash’ (WEPA), has been utilized for the first time as a renewable medium for Pd(OAc)2-catalysed Suzuki–Miyaura cross-coupling at room temperature. This method offers a simple and sustainable synthesis of biaryls from aryl halides and arylboronic acids under ligand- and external base-free aerobic and ambient conditions. This method has been found effective for both activated and unactivated aryl halides in the production of biaryls with moderate to nearly quantitative yields. The protocol shows high chemoselectivity over identical/similar reactive sites in aryl halides (i.e. selectivity over identical halogens or different halogens of aryl halides). This method exhibits high regioselectivity, i.e. the selective reactivity of a halogen over other identical halogens at different positions on the aromatic nucleus. Therefore, we disclose here a clean, benign, substantial chemo- and regioselective and highly economic alternative method for the palladium-assisted synthesis of biaryls using an agro waste-derived medium.

The dimethoxyphenylbenzyl protecting group: An alternative to the p-methoxybenzyl group for protection of carbohydrates

A reliable reagent system for the cleavage of 4-(3,4-dimethoxyphenyl)benzyl (DMPBn) ethers under acidic conditions has been established. Treatment of DMPBn-protected mono- and pseudodisaccharides with TFA in anhydrous CH 2Cl2 and 3,4-(methylenedioxy)toluene as a cation scavenger resulted in the selective cleavage of the DMPBn ether giving the corresponding deprotected products in moderate to high yields. Examples are reported which show that allyl, benzyl, and p-bromobenzyl ethers, esters, and glycosidic linkages are stable to these reaction conditions. The selective cleavage of allyl, p-bromobenzyl, and PMB ethers in protected carbohydrates containing DMPBn ethers are also demonstrated. This work establishes the 4-(3,4-dimethoxyphenyl) benzyl ether as an effective and robust alternative to p-methoxybenzyl as a protecting group for alcohols.