760987-73-3

Upstream product

• 873-75-6 4-bromobenzenemethanol 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 122294-03-5 methyl 3',4'-dimethoxybiphenyl-4-carboxylate 

Downstream Products

• 640769-65-9 3’,4’-dimethoxy-[1,1’-biphenyl]-4-carbaldehyde 
• 1434832-13-9 6-(4-(3,4-dimethoxyphenyl)benzyl)-3,4-(methylenedioxy)toluene 
• 1434821-10-9 6-(4-(3,4-dimethoxyphenyl)benzyl)-3,4-dimethoxytoluene 
• 1434821-18-7 6-(4-(3,4-dimethoxy-(6-(4-(3,4-dimethoxyphenyl)benzyl))phenyl)benzyl)-3,4-dimethoxytoluene 
• 1434820-92-4 3-(4-(3,4-dimethoxyphenyl)benzyl)-1,4-dimethoxybenzene 
• 1434820-98-0 3-(4-(3,4-dimethoxy-(6-(4-(3,4-dimethoxyphenyl)benzyl))phenyl)benzyl)-1,4-dimethoxybenzene 
• 1434821-04-1 3-(4-(3,4-dimethoxy-(6-( 4-(3,4-dimethoxy-(6-(4-( 3,4-dimethoxyphenyl)benzyl))phenyl)benzyl))phenyl)benzyl)-1,4-dimethoxybenzene 
• 760987-52-8 1,5-anhydro-3-O-benzyl-6-O-(3,4-dimethoxyphenyl)benzyl-2-deoxy-4-O-(4-methoxybenzyl)-D-arabinohex-1-enitol 

Relevant academic research and scientific papers

Predicting the structure of supramolecular dendrimers via the analysis of libraries of AB3 and constitutional isomeric AB2 biphenylpropyl ether self-assembling dendrons

The synthesis of 4′-hydroxy-4-biphenylpropionic, 3′,4′- dihydroxy-4-biphenylpropionic, 3′,5′-dihydroxy-4-biphenylpropionic, and 3′,4′,5′-trihydroxy-4-biphenylpropionic methyl esters via three efficient and modular strategies including one based on Ni-catalyzed borylation and sequential cross-coupling is reported. These building blocks were employed in a convergent iterative approach to the synthesis of one library of 3,4,5-trisubstituted and two libraries of constitutional isomeric 3,4- and 3,5-disubstituted biphenylpropyl ether dendrons. Structural and retrostructural analysis of supramolecular dendrimers revealed that biphenylpropyl ether dendrons self-assemble and self-organize into the same periodic lattices and quasi-periodic arrays observed in previously reported libraries, but with larger dimensions, different mechanisms of self-assembly, and improved solubility, thermal, acidic, and oxidative stability. The different mechanisms of self-assembly led to the discovery of two new supramolecular structures. The first represents a new banana-like lamellar crystal with a four layer repeat. The second is a giant vesicular sphere self-assembled from 770 dendrons that exhibits an ultrahigh molar mass of 1.73 × 106 g/mol. Thus, the enhanced size of the self-assembled structures constructed from biphenylpropyl ether dendrons permitted for the first time discrimination of various molecular mechanisms of spherical self-assembly and elaborated a continuum between small filled spheres and very large hollow spheres that is dictated by the primary structure of the dendron. The comparative analysis of libraries of biphenylpropyl ether dendrons with the previously reported libraries of benzyl-, phenylpropyl-, and biphenyl-4-methyl ether dendrons demonstrated biomimetic self-assembly wherein the primary structure of the dendron and to a lesser extent the structure of its repeat unit determines the supramolecular tertiary structure. A "nanoperiodic table" of self-assembling dendrons and supramolecular dendrimers that allows the prediction of the general features of tertiary structures from primary structures was elaborated.

A Suzuki-Miyaura coupling mediated deprotection as key to the synthesis of a fully lipidated malarial GPI disaccharide

Ligandless palladium-catalyzed Suzuki-Miyaura coupling converted an inert p-bromobenzyl ether to a DDQ-labile p-(3,4-dimethoxyphenyl) benzyl ether in the presence of azide functionality and this strategy serves as a key step for the convergent synthesis of a fully lipidated malaria GPI disaccharide.