64098-30-2Relevant academic research and scientific papers
6-Aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepines
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, (2008/06/13)
There are produced 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-(1,4)-diazepines of the formula: STR1 wherein R1 is hydrogen, a halogen atom, an alkyl group with 1 to 6 carbon atoms, a hydroxy group, an alkoxy group with 1 to 6 carbon atoms, a mercapto group, an alkyl mercapto group having 1 to 6 carbon atoms, an alkylsulfoxido group with 1 to 6 carbon atoms, an alkyl sulfono group with 1 to 6 carbon atoms, an amino group, an aliphatic acylamino group with 2 to 6 carbon atoms, a monoalkylamino group with 1 to 6 carb0n atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms in the ring, R2 is hydrogen, an alkyl group with 1 to 6 carbon atoms, a hydroxy group, an acyloxy group with 2 to 6 carbon atoms, an alkoxy group with 1 to 6 carbon atoms, a mercapto group, an alkylmercapto group with 1 to 6 carbon atoms, a halogen atom, an amino group, an aliphatic acylamino group with 2 to 6 carbon atoms, a monoalkylamino group with 1 to 6 carbon atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms in the ring, R3 is hydrogen, an alkyl group with 1 to 6 carbon atoms, an alkoxy group with 1 to 6 carbon atoms or a halogen atom, The structural part A--B is the group --N=N--, --CH2 --NH--, --CO--NR4, --C(SR5)=N--, --C(OR5)=N--, --C(NR5 R5)=N--, or --CR6 =N--, wherein R4 is hydrogen, an alkenyl group with 2 to 6 carbon atoms, an alkinyl group with 2 to 6 carbon atoms, a hydroxy-alkyl group with 1 to 6 carbon atoms, a ketoalkyl group with 1 to 6 atoms in the alkyl group, a cyanoalkyl group with 1 to 6 carbon atoms, an alkyl group with 1 to 6 carbon atoms, or an alkyl group of 1 to 6 carbon atoms substituted by an alkoxy group with 1 to 6 carbon atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms, R5 is hydrogen or an alkyl group with 1 to 6 carbon atoms, R6 is hydrogen, an alkyl group with 1 to 6 carbon atoms or a haloalkyl group with 1 to 6 carbon atoms, And Y--Z is the group >CH=N--, >C=N(→O), >CH--NH-- or >CH--N(OH)-- and wherein R6 is other than alkyl if R1 is chlorine, R2 is hydrogen, R3 is hydrogen or halogen and Y-Z is the group >C=N--, their optical isomers and their pharmaceutically acceptable salts. The compounds have anticonvulsive properties.
