64098-32-4

Usage

Uses

Used in Pharmaceutical Industry:
Zapizolam is used as a short-term treatment for insomnia and anxiety disorders, leveraging its sedative, anxiolytic, muscle relaxant, and hypnotic effects to alleviate symptoms and improve sleep quality.
Used in Medical Applications:
Zapizolam is used as a sedative and anxiolytic agent to manage symptoms of anxiety and promote relaxation in patients with anxiety disorders. Its muscle relaxant properties also make it useful for treating muscle tension and spasms associated with anxiety.
However, due to its potential for abuse, tolerance, and dependence, the use of zapizolam is generally limited to short-term therapy. Prescribers must exercise caution when prescribing this medication to minimize the risk of adverse effects and dependence.

InChI:InChI=1/C15H9Cl2N5/c16-10-4-2-1-3-9(10)14-15-11(5-6-12(17)20-15)22-8-19-21-13(22)7-18-14/h1-6,8H,7H2

Upstream product

• 64098-30-2 8-chloro-6-(2-chloro-phenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine 5-oxide 

Relevant academic research and scientific papers

6-Aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepines

There are produced 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-(1,4)-diazepines of the formula: STR1 wherein R1 is hydrogen, a halogen atom, an alkyl group with 1 to 6 carbon atoms, a hydroxy group, an alkoxy group with 1 to 6 carbon atoms, a mercapto group, an alkyl mercapto group having 1 to 6 carbon atoms, an alkylsulfoxido group with 1 to 6 carbon atoms, an alkyl sulfono group with 1 to 6 carbon atoms, an amino group, an aliphatic acylamino group with 2 to 6 carbon atoms, a monoalkylamino group with 1 to 6 carb0n atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms in the ring, R2 is hydrogen, an alkyl group with 1 to 6 carbon atoms, a hydroxy group, an acyloxy group with 2 to 6 carbon atoms, an alkoxy group with 1 to 6 carbon atoms, a mercapto group, an alkylmercapto group with 1 to 6 carbon atoms, a halogen atom, an amino group, an aliphatic acylamino group with 2 to 6 carbon atoms, a monoalkylamino group with 1 to 6 carbon atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms in the ring, R3 is hydrogen, an alkyl group with 1 to 6 carbon atoms, an alkoxy group with 1 to 6 carbon atoms or a halogen atom, The structural part A--B is the group --N=N--, --CH2 --NH--, --CO--NR4, --C(SR5)=N--, --C(OR5)=N--, --C(NR5 R5)=N--, or --CR6 =N--, wherein R4 is hydrogen, an alkenyl group with 2 to 6 carbon atoms, an alkinyl group with 2 to 6 carbon atoms, a hydroxy-alkyl group with 1 to 6 carbon atoms, a ketoalkyl group with 1 to 6 atoms in the alkyl group, a cyanoalkyl group with 1 to 6 carbon atoms, an alkyl group with 1 to 6 carbon atoms, or an alkyl group of 1 to 6 carbon atoms substituted by an alkoxy group with 1 to 6 carbon atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms, R5 is hydrogen or an alkyl group with 1 to 6 carbon atoms, R6 is hydrogen, an alkyl group with 1 to 6 carbon atoms or a haloalkyl group with 1 to 6 carbon atoms, And Y--Z is the group >CH=N--, >C=N(→O), >CH--NH-- or >CH--N(OH)-- and wherein R6 is other than alkyl if R1 is chlorine, R2 is hydrogen, R3 is hydrogen or halogen and Y-Z is the group >C=N--, their optical isomers and their pharmaceutically acceptable salts. The compounds have anticonvulsive properties.