64107-38-6Relevant academic research and scientific papers
GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
Bamborough, Paul,Barnett, Heather A.,Becher, Isabelle,Bird, Mark J.,Chung, Chun-Wa,Craggs, Peter D.,Demont, Emmanuel H.,Diallo, Hawa,Fallon, David J.,Gordon, Laurie J.,Grandi, Paola,Hobbs, Clare I.,Hooper-Greenhill, Edward,Jones, Emma J.,Law, Robert P.,Le Gall, Armelle,Lugo, David,Michon, Anne-Marie,Mitchell, Darren J.,Prinjha, Rab K.,Sheppard, Robert J.,Watson, Allan J. B.,Watson, Robert J.
supporting information, p. 552 - 557 (2016/07/06)
The BRPF (Bromodomain and PHD Finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. A selective benzimidazolone BRPF1 inhibitor showing micromolar activity in a cellular target engag
Copper-catalyzed efficient synthesis of a 2-benzimidazolone scaffold from 2-nitroaniline and dimethyl carbonate via a hydrosilylation reaction
Nale, Deepak B.,Bhanage, Bhalchandra M.
, p. 2480 - 2486 (2015/04/27)
This work reports a copper-catalyzed novel protocol for the tandem synthesis of 2-benzimidazolone derivatives from dimethyl carbonate (DMC) and various 2-nitroanilines by using polymethylhydrosiloxane (PMHS) as an inexpensive, stable and environmentally benign reducing agent. This methodology is applicable for the preparation of a broad range of biologically active 2-benzimidazolone derivatives with a good scope in good to excellent yields.
