64146-62-9

Upstream product

• 625-95-6 3-Iodotoluene 
• 64146-57-2 1-heptynylzinc chloride 
• 5663-96-7 oct-2-ynoic acid 
• 628-71-7 1-Heptyne 
• 591-17-3 meta-bromotoluene 
• 17933-03-8 m-tolylboronic acid 

Relevant academic research and scientific papers

Organophosphate-accelerated copper-catalyzed C(sp2)-C(sp) Sonogashira-type cross couplings

A dramatic acceleration in copper-catalyzed Sonogashira-type reactions was observed when an organophosphate was used as additive. The catalyst systems featuring low copper loading (0.5 mol% Cu 5 mol%) gave Sonogashira-type products with a broad scope

Synthesis of trisubstituted alkenes by Ni-catalyzed hydroalkylation of internal alkynes with cycloketone oxime esters

A method for Ni-catalyzed hydroalkylation of internal alkynes with cycloketone oxime esters was developed. The reaction has a broad substrate scope. This hydroalkylation shows excellent regio-and stereo-selectivity. This method enables readily available starting materials to be used to access a range of cyano-substituted single-configuration trisubstituted alkenes. These are valuable feedstock chemicals and are widely used in synthetic and medicinal chemistry.

Copper-catalyzed C(sp2)-C(sp) Sonogashira-type cross-coupling reactions accelerated by polycyclic aromatic hydrocarbons

Copper-catalyzed Sonogashira-type reactions were dramatically accelerated by introducing a catalytic amount of polycyclic aromatic hydrocarbon additive. This novel catalytic system features low copper loading (0.5mol% Cu 5mol%), broad reaction scope a

Synthesis, characterization of palladium hydroxysalen complex and its application in the coupling reaction of arylboronic acids: Mizoroki-Heck type reaction and decarboxylative couplings

(Salen-OH)Pd (1, salen-OHN,N′-bis(3,5-di-hydroxysalicylidene)- ethylenediamine) was prepared by a simple one step reaction and fully characterized by 1H and 13C NMR, IR spectroscopy, and X-ray crystallography. This palladium complex showed good activities as a catalyst in the Mizoroki-Heck-type reaction and the decarboxylative coupling reaction. In the Mizoroki-Heck type reaction, arylboronic acids and alkenes were reacted at 90°C for 3 h in the presence of 2.0 mol% of the palladium complex 1 and AgOAc to give the desired coupled product in good yields. In the decarboxylative coupling reactions, the desired coupled products were obtained in good yields when 0.5 mol% of the palladium complex was employed at room temperature.

Palladhim-catalyzed decarboxylative sp-sp2 cross-coupling reactions of aryl and vinyl halides and triflates with α,β-ynoic acids using silver oxide

Palladium-catalyzed decarboxylative sp-sp2 cross-coupling reactions of aryl and vinyl halides and triflates with α,β-ynoic acids using silver oxide have been developed. A variety of α,β-ynoic acids were readily decarboxylated in the presence of

Facile synthesis of substituted alkynes by cyclopalladated ferrocenylimine catalyzed cross-coupling of arylboronic acids/esters with terminal alkynes

A highly efficient and convenient catalytic system for the cross-coupling reaction of arylboronic reagents with terminal alkynes was described by using cyclopalladated ferrocenyhmine (I)/silver oxide as the catalyst at room temperature. This method provides the first examples of a palladacycle-catalyzed cross-coupling reaction of arylboronic acids/esters with terminal alkynes under mild conditions, and also a facile route for the synthesis of substituted alkynes with a low Pd loading of 1 mol-%. The substrates could be extended to electron-poor alkynes, for which the traditional Sonogashira reaction does not proceed. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.