6415-58-3Relevant academic research and scientific papers
Trans N-Methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] cycloprop-2-ene-1-carboxamides: Novel lipophilic kappa opioid agonists
Sabin,Horwell,McKnight,Broqua
, p. 291 - 296 (2007/10/03)
The synthesis and kappa opioid agonist activities of some lipophilic analogues of the kappa opioid agonist U-50488 incorporating motifs bearing two aromatic rings in place of the 3,4-dichlorophenyl group are described. Trans 2,3-diphenyl-N-methyl-N[2-(1-pyrrolidinyl)cyclohexyl]-2-cyclopropene-1 -carboxamide, 7, is a potent kappa opioid agonist. A diphenylcyclopropene analogue of CI-977, trans 2,3-diphenyl-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-2 -cyclopropene-1-carboxamide, 13, is a highly lipophilic chemically novel potent selective kappa opioid agonist.
The Attempted Generation of a Methylene-Bridged Trimethylenemethane Biradical (1,3-Diphenyl-2-methylenecyclobutane-1,3-diyl) by Oxidation of endo-1,3-Diphenyl-2-(phenylselenomethyl)bicyclobutane.
Bushby, Richard J.,Jesudason, Malini V.
, p. 1144 - 1170 (2007/10/02)
Copper-catalysed addition of ethyl diazoacetate to diphenylacetylene and hydrolysis gives 1,2-diphenylcyclopropane-3-carboxylic acid (18b).Conversion to the acid chloride (18c) and reduction with lithium aluminium tri-tert-butoxy hydride gives 1,2-dipheny
Small Rings, 33. Attempts to Synthesize Diphenyltetrahedrane
White, Emil H.,Winter, Rudolph E. K.,Graeve, Rolf,Zirngibl, Ulrich,Friend, Earl W.,et al.
, p. 3906 - 3915 (2007/10/02)
Carbene 7, formed on photochemical or thermal excitation of (2,3-diphenyl-2-cyclopropen-1-yl)diazomethane (6i), splits mostly into two acetylenes 8 and 9 instead of undergoing an intramolecular cycloaddition.Photolysis of the Masamune ketone 16 depending on the reaction conditions gives either p-terphenyl or a mixture of the two cyclooctatetraens 18 and 19.The intermediate formation of tetrahedrane 10 would fit into the mechanistic picture of this fragmentation.
