64152-91-6Relevant academic research and scientific papers
CH-Acidity of Amino-acid Esters co-ordinated to Cobalt(III). Racemization during the Formation of Peptides
Wautier, Henry,Marchal, Daniel,Fastrez, Jacques
, p. 2484 - 2488 (1981)
Several dipeptide complexes of general formula 3 have been obtained by coupling a chelated ester complex with a free amino-acid ester.The rate of the reaction appears to be quite sensitive to steric hindrance.With chiral amino-acids, the product is a mixture of diastereomers; this result is consistent with a fast racemization coupled with a slight asymmetric induction.The half-life for proton exchange in the complex 3 under the conditions of peptide synthesis is 20 s.The hydrolysis of this ester in methanol (1mol dm-3 in H2O) is nevertheless faster than racemization.
