64154-79-6

Upstream product

• 64154-78-5 4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride 
• 147-85-3 L-proline 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 1486-53-9 4-(benzyloxy)-3-methoxybenzoic acid 
• 100-44-7 benzyl chloride 

Downstream Products

• 132622-08-3 (S)-1-(4-Benzyloxy-5-methoxy-2-nitro-benzoyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 176387-50-1 (S)-1-(4-Benzyloxy-5-methoxy-2-nitro-thiobenzoyl)-pyrrolidine-2-carbothioaldehyde 
• 482378-30-3 2-(10-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-decyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-35-8 2-(10-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-decyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-29-0 2-(8-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-octyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-34-7 2-(8-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-octyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-28-9 2-(5-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-33-6 2-(5-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-26-7 2-(4-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-32-5 2-(4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-25-6 2-(3-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-propyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-38-1 1-{4-[5-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-pentyloxy]-5-methoxy-2-nitro-benzoyl}-pyrrolidine-2-carboxylic acid methyl ester 
• 482378-31-4 2-(3-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-propyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-37-0 1-{4-[4-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-butoxy]-5-methoxy-2-nitro-benzoyl}-pyrrolidine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Design and synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrids as anti-tumour agents

The facile synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrid analogues is described. The compounds are prepared with varying degrees of linker length in order to probe the structural requirements for optimal in vitro anti-tumour activity. Some of these new hybrid compounds showed higher cytotoxic activity than the existing natural and synthetic pyrrolo[2,1-c][1,4]benzodiazepines.

A new facile procedure for the preparation of pyrrolo[2,1-c][1,4]benzodiazepines : Synthesis of the antibiotic DC-81 and its thio analogue

An efficient synthesis of the imine form of the pyrrolo[2,1-c][1,4] benzodiazepine ring system based on a new reductive cyclization procedure is described. The naturally occuring antibiotic DC-81(5c) and its 5-thio analogue (7c) have also been synthesized to illustrate the usefulness of this methodology.

New approaches to pyrrolo[2,1-c][1,4]benzodiazepines: Synthesis, DNA-binding and cytotoxicity of DC-81

Two routes to the naturally occuring DNA-binding antitumor antibiotic DC-81 are described, one of which involves a novel cyclization process based on acid resin. The second route involves the synthesis of a new compound, 6-nitrovanillic acid, a key A-ring component of many naturally occuring PBDs. These routes have provided a sufficient quantity of DC-81 to allow complete characterization and evaluation in DNA-binding and in vitro cytoxicity studies.