641570-12-9

Basic information

• Product Name: C₂₀H₁₆N₆OS
• Synonyms: C₂₀H₁₆N₆OS
• CAS NO: 641570-12-9
• Molecular Weight: 388.453
• Mol File: 641570-12-9.mol

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₆N₆OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₆N₆OS(641570-12-9)
• EPA Substance Registry System: C₂₀H₁₆N₆OS(641570-12-9)

Safety Data

• Hazardous Substances Data: 641570-12-9(Hazardous Substances Data)

Upstream product

• 641569-95-1 C₁₁H₁₅N₃O₂ 
• 641569-94-0 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid 
• 96-50-4 2-thiazolylamine 
• 1205540-17-5 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoyl chloride 
• 641569-97-3 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester 
• 641569-96-2 3-guanidino-4-methylbenzoic acid ethyl ester nitrate 
• 41191-92-8 3-amino-4-methylbenzoic acid ethyl ester 
• 2458-12-0 3-amino-p-toluic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors

A series of pyridin-3-yl pyrimidines was synthesized and evaluated for their Bcr-Abl inhibitory and anticancer activity. The preliminary results indicated that some compounds were promising anticancer agents. Compounds A2, A8, and A9 exhibited potent Bcr-Abl inhibitory activity, suggesting that aniline containing halogen substituents might be important for biological activity. Molecular docking was carried out to investigate the binding mode of them with Bcr-Abl. Details of synthesis and SAR studies of these compounds are described. A series of phenylaminopyrimidines was designed and synthesized as potent Bcr-Abl inhibitors. The screening of these rationally designed compounds for antitumor activity had identified three candidate leads which could be further optimized to improve the anticancer activities.