64161-84-8Relevant academic research and scientific papers
α-D-Ribofuranosyl 1,2-Cyclic Monophosphate. Isolation, NMR Spectroscopic Properties, and Rates and Mechanism of Acid and Alkaline Hydrolysis
Fathi, Reza,Jordan, Frank
, p. 4143 - 4146 (1986)
The five-membered ring cyclic phosphate α-D-ribofuranosyl 1,2-cyclic phosphate has been synthesized, isolated, and characterized both spectroscopically and with respect to acid and alkaline lability.The 31P NMR chemical shift (17 ppm downfield from intern
Kinetic and NMR spectroscopic study of the chemical stability and reaction pathways of sugar nucleotides
Jaakkola, Juho,Nieminen, Anu,Kivel?, Henri,Korhonen, Heidi,T?htinen, Petri,Mikkola, Satu
, p. 178 - 193 (2020/12/21)
The alkaline cleavage of two types of sugar nucleotides has been studied by 1H and 31P NMR in order to obtain information on the stability and decomposition pathways in aqueous solutions under alkaline conditions. The reaction of glucose 1-UDP is straightforward, and products are easy to identify. The results obtained with ribose 5-UDP and ribose 5-phosphate reveal, in contrast, a more complex reaction system than expected, and the identification of individual intermediate species was not possible. Even though definite proof for the mechanisms previously proposed could not be obtained, all the spectroscopic evidence is consistent with them. Results also emphasise the significant effect of conditions, pH, ionic strength, and temperature, on the reactivity under chemical conditions.
