641611-53-2

Basic information

• Product Name: 1,3-bis-tert-butoxycarbonyl-1-(3'-benzyloxybenzyl)-2-methyl-2-thiopseudourea
• Synonyms: 1,3-bis-tert-butoxycarbonyl-1-(3'-benzyloxybenzyl)-2-methyl-2-thiopseudourea
• CAS NO: 641611-53-2
• Molecular Weight: 486.632
• Mol File: 641611-53-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-bis-tert-butoxycarbonyl-1-(3'-benzyloxybenzyl)-2-methyl-2-thiopseudourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis-tert-butoxycarbonyl-1-(3'-benzyloxybenzyl)-2-methyl-2-thiopseudourea(641611-53-2)
• EPA Substance Registry System: 1,3-bis-tert-butoxycarbonyl-1-(3'-benzyloxybenzyl)-2-methyl-2-thiopseudourea(641611-53-2)

Safety Data

• Hazardous Substances Data: 641611-53-2(Hazardous Substances Data)

Upstream product

• 1700-31-8 3-benzyloxybenzyl bromide 
• 107819-90-9 1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 

Downstream Products

• 641611-54-3 17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-5'-bis-tert-butoxycarbonyl-(N'-3-benzyloxybenzyl)guanidinyl-3,14-dihydroxyindolo[2',3':6,7]morphinan 

Relevant articles and documents

Guanidino N-Substituted and N,N-Disubstituted Derivatives of the κ-Opioid Antagonist GNTI

Derivatives of the highly selective κ-opioid receptor antagonist GNTI (2a) have been prepared. Binding and functional studies conducted on cloned human opioid receptors expressed in Chinese hamster ovarian (CHO) cells suggested that adding a benzyl or a substituted benzyl group to the guanidino moiety led, in general, to a retention of high κ-affinity and antagonist potency. Disubstitution of the guanidino moiety led to reduced κ-selectivity.