641613-25-4Relevant academic research and scientific papers
Asymmetric Total Synthesis of 19,20-Epoxydocosapentaenoic Acid, a Bioactive Metabolite of Docosahexaenoic Acid
Cinelli, Maris A.,Lee, Kin Sing Stephen
, p. 15362 - 15372 (2019/11/28)
In this study, we report the first asymmetric total synthesis of 19,20-epoxydocosapentaenoic acid (19,20-EDP), a naturally occurring bioactive cytochrome P450 metabolite of docosahexaenoic acid, a major constituent of fish oil. Our strategy involves direct asymmetric epoxidation to produce an enantiopure β-epoxyaldehyde that can be appended to the rest of the skipped polyene core by Wittig condensation. Our route is step-economical and late divergent and could be an appealing method by which to synthesize EDP analogues for biological studies.
Immobilizing of oxo-molybdenum complex on cross-linked copolymer and its catalytic activity for epoxidation reactions
Fan, Weizheng,Shi, Dongyang,Feng, Bainian
, p. 1 - 4 (2015/11/10)
This work describes the immobilization of molybdenum acetylacetonate oxygen (MoO2(acac)2) on cross-linked porous copolymer support via covalent attachment under mild conditions. The obtained solid product DVB-AA-Mo was fully characterized by FT-IR, TG, CHN elemental analysis, nitrogen adsorption/desorption, and SEM, and was tested for the epoxidation of various alkenes with tert-butyl hydroperoxide (TBHP) as the oxidant. DVB-AA-Mo was proved to be a highly efficient catalyst for epoxidation reactions, it could easily be recovered by filtration and reused for five runs without significant loss in activity.
