641626-91-7

Upstream product

• 641626-92-8 3-(5-methyl-3-phenylisoxazol-4-yl)-2,4-dihydroindeno[1,2-c]pyrazole-6-carboxylic acid 
• 530-62-1 1,1'-carbonyldiimidazole 
• 74-89-5 methylamine 
• 641626-87-1 6-bromo-3-(5-methyl-3-phenylisoxazol-4-yl)-1,4-dihydroindeno[1,2-c]pyrazole 

Relevant academic research and scientific papers

Isoxazole pyrazoloindane derivatives as cognition enhancing GABA-A alpha 5 subtype ligands

The present invention provides compounds of formula I: 1 in which:one of X and Y is a nitrogen atom substituted by a group R6′ and the other is a carbon atom substituted by an isoxazole group substituted on its carbon atoms by groups R3 and R4;one of R6 and R6′ is hydrogen;either all of W1, W2, W3 and W4 are carbon or one of W1, W2, W3 and W4 is nitrogen and the rest are carbon;and R1 and R2 are, independently, a small group, heteroaromatic ring or a 4-7 membered cyclic amine ring; processes for making them; pharmaceutical composition containing them; their use in therapy, particularly for enhancing cognition in conditions such as Alzheimer''s Disease; and methods of treatment using them.