641637-70-9Relevant academic research and scientific papers
Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. Part 4: Biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries
Ferraris, Dana,Ficco, Rica Pargas,Dain, David,Ginski, Mark,Lautar, Susan,Lee-Wisdom, Kathy,Liang, Shi,Lin, Qian,Lu, May X.-C.,Morgan, Lisa,Thomas, Bert,Williams, Lawrence R.,Zhang, Jie,Zhou, Yinong,Kalish, Vincent J.
, p. 3695 - 3707 (2007/10/03)
A class of poly(ADP-ribose) polymerase (PARP-1) inhibitors, the imidazobenzodiazepines, are presented in this text. Several derivatives were designed and synthesized with ionizable groups (i.e., tertiary amines) in order to promote the desired pharmaceuti
