328546-65-2Relevant articles and documents
USE OF SUBSTITUTED BENZODIAZEPINONES AND BENZAZEPINONES OR THE SALTS THEREOF AS ACTIVE SUBSTANCES AGAINST ABIOTIC PLANT STRESS
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, (2015/09/22)
The use of substituted benzodiazepinones and benzazepinones of the general formula (I) or salts thereof where the radicals in the general formula (I) correspond to the definitions given in the description, for enhancing stress tolerance in plants to abiot
Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors
Skalitzky, Donald J.,Marakovits, Joseph T.,Maegley, Karen A.,Ekker, Anne,Yu, Xiao-Hong,Hostomsky, Zdenek,Webber, Stephen E.,Eastman, Brian W.,Almassy, Robert,Li, Jianke,Curtin, Nicola J.,Newell, David R.,Calvert, A. Hilary,Griffin, Roger J.,Golding, Bernard T.
, p. 210 - 213 (2007/10/03)
Novel tricyclic benzimidazole carboxamide poly-(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful chemopotentiators of temozolomide and topotecan in both A549 and LoVo cell lines. In vitro inhi
Design and synthesis of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. Part 4: Biological evaluation of imidazobenzodiazepines as potent PARP-1 inhibitors for treatment of ischemic injuries
Ferraris, Dana,Ficco, Rica Pargas,Dain, David,Ginski, Mark,Lautar, Susan,Lee-Wisdom, Kathy,Liang, Shi,Lin, Qian,Lu, May X.-C.,Morgan, Lisa,Thomas, Bert,Williams, Lawrence R.,Zhang, Jie,Zhou, Yinong,Kalish, Vincent J.
, p. 3695 - 3707 (2007/10/03)
A class of poly(ADP-ribose) polymerase (PARP-1) inhibitors, the imidazobenzodiazepines, are presented in this text. Several derivatives were designed and synthesized with ionizable groups (i.e., tertiary amines) in order to promote the desired pharmaceuti