641638-38-2

Upstream product

• 259529-54-9 (4S)-3-(1-oxo-2-propen-1-yl)-4-phenyl-1,3-oxazolidin-2-one 
• 641638-37-1 2-(4-bromophenyl)propane-1,3-dioic acid bis(1,1-dimethylethyl) ester 
• 589-87-7 1,4-bromoiodobenzene 
• 541-16-2 t-butyl malonate 

Downstream Products

• 641638-42-8 2-{4-[(S)-1-((S)-2-tert-Butoxycarbonyl-1-{1-[(S)-2-carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-allyl]-phenyl}-malonic acid di-tert-butyl ester 
• 641638-43-9 2-(4-((9S,10S,14S,18S)-7,16,19-triaza-9-{[(tert-butyl)oxycarbonyl]methyl}-18-(carbamoylmethyl)-14-(naphthylmethyl)-8,17,20-trioxospiro[5,14]icos-11-en-10-yl)phenyl)propane-1,3-dioic acid bis(1,1-dimethylethyl) ester 
• 641638-40-6 2-[4-(3-((4S)-2-oxo-4-phenyl)-(1,3-oxazolidin-3-yl))]-(1S,2S)-2-{[(tert-butyl)oxycarbonylmethyl-3-oxo-1-vinylpropyl]phenyl}propane-1,3-dioic acid bis(1,1-dimethylethyl) ester 
• 641638-41-7 (2S,3S)-3-(4-{bis[(tert-butyl)oxycarbonyl]methyl}-phenyl)-2-{[(tert-butyl)oxycarbonyl]methyl}-pent-4-enoic acid 
• 641638-39-3 2-{4-[(1R)-3-((4S)-2-oxo-4-phenyl-(1,3-oxazolidin-3-yl))-3-oxo-1-vinylpropyl]phenyl}propane-1,3-dioic acid bis(1,1-dimethylethyl) ester 

Relevant academic research and scientific papers

Macrocyclization in the Design of Non-Phosphorus-Containing Grb2 SH2 Domain-Binding Ligands

Macrocyclization from the phosphotyrosyl (pTyr) mimetic's β-position has previously been shown to enhance Grb2 SH2 domain-binding affinity of phosphonate-based analogues. The current study examined the effects of such macrocyclization using a dicarboxymethyl-based pTyr mimetic. In extracellular assays affinity was enhanced approximately 5-fold relative to an open-chain congener. Enhancement was also observed in whole-cell assays examining blockade of Grb2 binding to the erbB-2 protein-tyrosine kinase.