259529-54-9

Upstream product

• 79-10-7 acrylic acid 
• 2051-76-5 acrylic acid anhydride 
• 99395-88-7 (S)-4-phenyl-2-oxazolidinone 
• 814-68-6 acryloyl chloride 
• 145941-30-6 acrylic pivalic anhydride 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 641638-38-2 2-{4-[(1E)-3-((4S)-2-oxo-4-phenyl-(1,3-oxazolidin-3-yl))-3-oxoprop-1-enyl]phenyl}propane-1,3-dioic acid bis(1,1-dimethylethyl) ester 
• 852714-83-1 Benzyl-{4-[(E)-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propenyl]-benzyl}-phosphinic acid tert-butyl ester 
• 1197006-82-8 (2'S,2R,3S)-{[3,4-dihydro-2-(4-nitrophenyl)-5-phenyl-2H-pyrrol-3-yl]-carbonyl}-2-oxo-4-phenyloxazolidine 
• 1257664-67-7 (S)-3-((2S,3S)-3-(3,5-di-tert-butylphenyl)-2-((dimethyl(phenyl)silyl)methyl)-3-hydroxy-propanoyl)-4-phenyloxazolidin-2-one 
• 1257664-69-9 (S)-3-((2S,3S)-2-((dimethyl(phenyl)silyl)methyl)-3-(4-fluorophenyl)-3-hydroxypropanoyl)-4-phenyloxazolidin-2-one 
• 1257664-66-6 (S)-3-((2S,3S)-2-((dimethyl(phenyl)silyl)methyl)-3-hydroxy-phenylpropanoyl)-4-phenyloxazolidin-2-one 
• 1257664-68-8 (S)-3-((2S,3S)-2-((dimethyl(phenyl)silyl)methyl)-3-hydroxy-3-(4-methoxyphenyl)propanoyl)-4-phenyloxazolidin-2-one 
• 1374995-74-0 C₁₈H₁₅NO₄ 
• 1374995-56-8 C₃₅H₂₉NO₇ 
• 1374995-54-6 C₃₅H₂₉NO₇ 
• 1595280-39-9 (4S)-3-((1R,2S)-2-(4-hydroxy-3-methoxyphenyl)cyclohex-3-enecarbonyl)-4-phenyloxazolidin-2-one 
• 189028-93-1 (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione 

Relevant academic research and scientific papers

Diastereoselective Copper-Mediated Conjugate Addition of Functionalized Magnesiates for the Preparation of Bisaryl Nrf2 Activators

A two-step metal-halogen exchange and diastereoselective copper-mediated Michael addition onto a complex α,β-unsaturated system has been developed and applied toward the synthesis of bisaryl Nrf2 activators. Optimization of metal-halogen exchange using (n

Preparation method of ezetimibe intermediate

The invention discloses a preparation method of an ezetimibe intermediate. The intermediate is (S)-1-(4-fluorophenyl)-5-(2-oxo-phenyloxazolidinyl-3-yl)pentane-1, 5-dione. The preparation method comprises that 1-(4-fluorophenyl)ethanone and a silane protective agent undergo a reaction to produce ((1-(4-fluorophenyl)vinyl)oxo)trimethylsilane, (S)-4-phenyloxazolidin-2-one and acryloyl chloride undergo a condensation reaction to produce (S)-3-acrylyl-4-phenyloxazolidin-2-one, and the ((1-(4-fluorophenyl)vinyl)oxo)trimethylsilane and the (S)-3-acrylyl-4-phenyloxazolidin-2-one undergo a condensation reaction to produce the ezetimibe intermediate. The preparation method utilizes a convergent type route, has the total yield of 80% or more, utilizes cheap and easily available raw materials, utilizes less types of solvents, produces small toxicity, has a short production period, utilizes simple production units operated easily, is safe and environmentally friendly and is very suitable for industrial production.

Synthetic studies of cyclic peptides stephanotic acid methyl ester, celogentin C, and moroidin

An account of the total synthesis of stephanotic acid methyl ester and celogentin C is presented. The present synthesis features a tandem asymmetric Michael addition/bromination sequence for the synthesis of leucine-tryptophan moiety, and an oxidative coupling reaction to form the tryptophan-imidazole linkage. Moreover, the total synthesis of moroidin had also been studied, and three different synthetic strategies for the construction of the right-hand ring of moroidin were studied.

Straightforward and facile synthesis of a bioactive component from zingiber cassumunar ROXB.

Straightforward and facile synthesis of a bioactive component A from Zingiber cassumunarRoxb. is described. The phenylbutenoid dimer A was reported to possess anti-inflammatory and cytotoxic activities. The optically active cyclohexene ring fragment was o

Diastereoselective aziridination of chiral electron-deficient olefins with N-chloro-N-sodiocarbamates catalyzed by chiral quaternary ammonium salts

Chiral quaternary ammonium salt-catalyzed diastereoselective aziridination of electron-deficient olefins that possess a chiral auxiliary with N-chloro-N-sodiocarbamates was developed. The key to high stereoselectivity was found to be the employment of the

Copper-catalysed domino silylative aldol reaction leading to stereocontrolled chiral quaternary carbons

(Chemical Equation Presented) Asymmetric aldol reaction: A domino silylation-aldol reaction between enoyloxazolidinones and various aldehydes has been developed (see scheme). The process catalysed by a copper complex in the presence of a borosilane led to high diastereoselectivities. Yields between 59 and 90 % and d.r. values between 78:22 to 95:5 were obtained. When methacryloyloxazolidinones were used, a controlled chiral quaternary carbon was generated. BPin=4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl.

Nitrile Ylides: Diastereoselective cycloadditions using chiral oxzolidinones without Lewis acid

"Chemical Equation Presented" Lewis acid complexation Is generally required for chiral-auxiliary-controlled stereoselectivity, and chiral Lewis acid catalysis Is frequently optimal for Introducing asymmetry. In this work, we show that nitrlle ylide cycloadditions to electron-poor acceptors attached to chiral auxiliaries proceed In high yield and stereoselectivity in the absence of Lewis acids. In contrast, chiral Lewis acids are Inferior In these cycloadditions.

2-OXAZOLIDINONES AND THEIR USE AS INHIBITORS OF ANIMAL CELL MOTILITY AND GROWTH

Cell motility and growth inhibitors, including compounds of the general structural formula (I), and use of the cell motility and cell growth inhibitors, and pharmaceutically acceptable salts, pro-drugs, and solvates thereof, as therapeutic agents, are disclosed.

Olefin Metathesis in the Design and Synthesis of a Globally Constrained Grb2 SH2 Domain Inhibitor

(matrix presented) One drawback frequently associated with olefin metathesis-mediated peptide macrocyclization, the loss of side chain functionality at sites of ring closure, may be circumvented by incorporation of side chain functionality within the ring